Tumor gene co-expression network construction method and device, equipment and storage medium

A network construction and tumor gene technology, applied in the field of devices, tumor gene co-expression network construction methods, equipment and storage media, can solve problems such as inability to realize multiple cancer network data mining

Active Publication Date: 2021-06-04
SHENZHEN POLYTECHNIC +1
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  • Claims
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Problems solved by technology

[0004] In related technologies, when using corresponding algorithms and / or models to predict cancer markers, usually an algorithm and / or model can only perform simple predictions on the network construction of one type of cancer, but cannot realize the prediction of multiple cancers. web data mining

Method used

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  • Tumor gene co-expression network construction method and device, equipment and storage medium
  • Tumor gene co-expression network construction method and device, equipment and storage medium
  • Tumor gene co-expression network construction method and device, equipment and storage medium

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Embodiment Construction

[0054] In order to make the above objects, features and advantages of the present application more obvious and understandable, the present application will be further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0055]refer to figure 1 with figure 2 , shows a flowchart of a method for constructing a tumor gene co-expression network in the present application. Such as figure 1 As shown, the method includes the following steps:

[0056] S101. Obtain the cancerous transcriptome sequencing data of various tissues in the target human body system and the normal transcriptome sequencing data of the various tissues; the target human body system is any one of the eight major human body systems in human anatomy.

[0057] From an anatomical point of view, there are eight major systems in the human body: motor system, nervous system, endocrine system, circulatory system, respiratory system, digestive system, urinary sys...

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Abstract

The invention provides a tumor gene co-expression network construction method and device, equipment and a storage medium. The method comprises the following steps: acquiring multiple tissue canceration transcriptome sequencing data and normal transcriptome sequencing data of multiple tissues in a target human body system, wherein the target human body system is any one human body system in eight human body systems of human anatomy; extracting mRNA, lncRNA and miRNA with difference in canceration transcriptome sequencing data of various tissues according to a relationship between genes and transcripts and RNA with uniform gene expression quantity in normal transcriptome sequencing data; carrying out GO analysis on canceration difference mRNA, lncRNA and miRNA of the plurality of tissues to obtain a target expression matrix fused with the mRNA, lncRNA and miRNA; and performing WGCNA analysis on the target expression matrix, constructing expression modules according to characters, and performing network construction on the module with the highest correlation. Network construction of various cancers can be realized.

Description

technical field [0001] The present application relates to the field of biological information technology, in particular to a method, device, equipment and storage medium for constructing a tumor gene co-expression network. Background technique [0002] Cancer is a disease caused by genetic or epigenetic canceration, specifically due to the mutation of proto-oncogene and tumor suppressor gene, the growth and division of normal cells are out of control and become cancer cells, and then manifested pathologically Cancer-related symptoms. The early human research method for cancer was to compare and analyze the genes and / or genome regions and proteins of cancer cells with the genes and / or genome regions of healthy cells and the proteins of cancer cells, so as to find the pathogenesis and treatment method. Although this early research method can screen out reliable cancer markers, it will consume a lot of time and financial resources during the experiment, which seems traditiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16B25/00
CPCG16B5/00G16B25/00
Inventor 徐磊王彦苏邹权
Owner SHENZHEN POLYTECHNIC
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