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Immune complex vaccine

An immune complex and vaccine technology, applied in the field of biomedicine, can solve the problems of difficulty in mass production of polyclonal antibodies and difficulty in controlling the quality of polyclonal antibodies, and achieve the effect of improving the effect of vaccine immunity, improving the effect of vaccine immunity, and maintaining stable quality.

Inactive Publication Date: 2021-06-11
陈继明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to prepare polyclonal antibodies in large quantities, and the quality of polyclonal antibodies is difficult to control. Some polyclonal antibodies also contain some pathogenic microorganisms
Therefore, this type of inactivated vaccine or protein vaccine that uses homologous specific polyclonal antibodies to enhance the immune effect has not been widely used in production practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 has set forth the preparation method of a kind of immune complex vaccine of preventing H9 subtype avian influenza and murine coronavirus type 3. Embodiment 1 is to illustrate the specific application of the present invention. This embodiment is not used to limit the application scope of the present invention and the protection scope of the patent of the present invention.

[0014] The vaccine described in Example 1 is an immune complex vaccine for inoculating mice. It contains two recombinant proteins (HA1 protein of H9 subtype avian influenza virus and S1 protein of mouse coronavirus type 3) prepared by genetic engineering. Both proteins contain the B cell epitope His-Tag (a small peptide composed of 6 histidines), and both use this B cell epitope to form an immune complex with the mouse anti-His-Tag monoclonal antibody things.

[0015] The preparation of the vaccine described in Example 1 includes the following five steps. First, entrust a relevant bi...

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Abstract

The invention relates to the technical field of biological medicines, in particular to an immune complex vaccine. The vaccine can be prepared by adding a homologous specific monoclonal antibody in a conventional vaccine preparation process, but not limited to the conventional vaccine preparation process. The vaccine is characterized in that any live virus does not need to be added, and the vaccine contains an immune complex formed by mutual combination of a protein antigen and a specific homologous monoclonal antibody thereof. The immune complex can improve the level of a vaccine-induced specific antibody and improve vaccine-induced specific cellular immunity. The vaccine has the advantages of being good in safety, excellent in immune protection effect, suitable for preventing various virus diseases and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the development, production and application of vaccines for the prevention of viral diseases of humans and animals, and can be used for the prevention of various viral diseases of humans and animals, the prevention and treatment of other diseases, and the physiological regulation of animals. Background technique [0002] Vaccines are an important substance to prevent viral diseases. Some vaccines are also used in the treatment of hepatitis B and cancer. Some vaccines, such as castration and growth-promoting vaccines, also modulate the physiology of animals. There are many types of vaccines that have been approved for use or are being studied, including live attenuated vaccines, inactivated vaccines, protein vaccines, nucleic acid vaccines, and viral vector vaccines. [0003] All of the above vaccines have some advantages and some disadvantages. Among them, inactivated vaccin...

Claims

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Application Information

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IPC IPC(8): A61K39/215A61K39/17A61K39/385A61K39/12A61P31/14A61P31/20A61P31/22
CPCA61K39/12A61K39/385A61P31/14A61P31/20A61P31/22C12N2770/20034C12N2760/16134C12N2760/18134A61K2039/6056A61K2039/70
Inventor 陈继明
Owner 陈继明
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