A quantitative method for chemical exchange saturation transfer effects in vivo
A technology of chemical exchange and transfer effect, applied in the field of magnetic resonance imaging, can solve the problem of low quantitative results, and achieve the effect of less sampling data and shorter sampling time
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[0038] This example was carried out on a Bruker 7T magnetic resonance imager (BioSpec 70 / 20). The experimental subjects were healthy SD (Sprague-Dawley) rats, weighing 309 g, for brain imaging. Use a mixed gas of about 4% isoflurane to induce anesthesia in rats, use a mixed gas of 1-2% isoflurane to maintain the anesthetized state of the rats, use a circulating water bath device to maintain a stable body temperature of the rats, and monitor the breathing to keep it at 50 times / minute or so. Use birdcage coil excitation and 4-channel array coil reception.
[0039] In this embodiment, the chemical exchange saturation transfer effect of amide protons in rat brain is taken as an example to illustrate, and the signal site is 3.5 ppm. The present invention can be used not only for animals, but also for human bodies.
[0040] A quantitative method for the chemical exchange saturation transfer effect in vivo, comprising the following steps:
[0041] Step 1, such as figure 1 As sh...
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