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A quantitative method for chemical exchange saturation transfer effects in vivo

A technology of chemical exchange and transfer effect, applied in the field of magnetic resonance imaging, can solve the problem of low quantitative results, and achieve the effect of less sampling data and shorter sampling time

Active Publication Date: 2022-04-01
INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method requires certain prior knowledge for point selection, and the quantitative results are low

Method used

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  • A quantitative method for chemical exchange saturation transfer effects in vivo
  • A quantitative method for chemical exchange saturation transfer effects in vivo
  • A quantitative method for chemical exchange saturation transfer effects in vivo

Examples

Experimental program
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Embodiment

[0038] This example was carried out on a Bruker 7T magnetic resonance imager (BioSpec 70 / 20). The experimental subjects were healthy SD (Sprague-Dawley) rats, weighing 309 g, for brain imaging. Use a mixed gas of about 4% isoflurane to induce anesthesia in rats, use a mixed gas of 1-2% isoflurane to maintain the anesthetized state of the rats, use a circulating water bath device to maintain a stable body temperature of the rats, and monitor the breathing to keep it at 50 times / minute or so. Use birdcage coil excitation and 4-channel array coil reception.

[0039] In this embodiment, the chemical exchange saturation transfer effect of amide protons in rat brain is taken as an example to illustrate, and the signal site is 3.5 ppm. The present invention can be used not only for animals, but also for human bodies.

[0040] A quantitative method for the chemical exchange saturation transfer effect in vivo, comprising the following steps:

[0041] Step 1, such as figure 1 As sh...

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Abstract

The invention discloses a quantitative method for the chemical exchange saturation transfer effect of a living body. The B0 distribution map of the main magnetic field is obtained by sampling; without applying a gradient, the chemical exchange sites of exchangeable protons are selectively saturated by saturation pulses, and the first is obtained by sampling. Signal intensity; applying a gradient while selectively saturating the chemical exchange sites of the exchangeable protons by a saturation pulse, sampling to obtain a second signal intensity; without applying a gradient or a saturation pulse, sampling to obtain an initial signal intensity; calculating normalization chemical exchange saturation transfer effect. The method of the invention has important practical value, can be applied to animals and human bodies, and the quantitative result is not affected by the magnetization transfer effect and the nuclear Euclidean effect in the living body.

Description

technical field [0001] The invention belongs to the field of magnetic resonance imaging methods, and in particular relates to a quantitative method for the chemical exchange saturation transfer effect of a living body. The invention is suitable for quantifying the saturation transfer effect of endogenous or exogenous chemical exchange in the magnetic resonance imaging of the living body, and the quantitative result is not affected by the magnetization transfer effect and the nuclear Euclidean effect in the living body. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is a commonly used clinical medical imaging method at present. It has the advantages of non-invasive, non-ionizing radiation, and no limitation of tissue penetration depth, etc., and can provide rich contrast information. However, the development of magnetic resonance molecular imaging technology is limited by detection sensitivity and spatial resolution. [0003] Chemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/0033
Inventor 周欣袁亚平娄昕郭茜旎孙献平叶朝辉
Owner INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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