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A method for preparing liposome microcapsule long-acting mosquito repellent ointment by using plant essential oil

A plant essential oil and liposome technology, applied in the field of biomedicine, can solve the problems of poor mosquito repellent effect, volatile lemon eucalyptus essential oil, poor heat sensitivity, etc., and achieves the advantages of preventing essential oil volatilization, prolonging mosquito repellent time, and improving stability. Effect

Active Publication Date: 2022-01-28
GUANGXI FORESTRY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a method for preparing liposome microcapsules long-acting mosquito repellent ointment by using plant essential oils to solve the problems of easy volatilization, poor thermal sensitivity and poor mosquito repelling effect of essential oils of lemon eucalyptus oil and Java citronella oil

Method used

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  • A method for preparing liposome microcapsule long-acting mosquito repellent ointment by using plant essential oil

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of method utilizing plant essential oil to prepare liposome microcapsule long-acting mosquito repellent ointment, comprises the steps:

[0030] S1: Dissolve p-menthane-3,8-diol and Java citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:2 Carry out ultrasonic emulsification with Polyethylene Glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 1.8% of Javanese citronella quality;

[0031] S2: Make a mixture of soybean lecithin, cholesterol, squash gum, propylene glycol alginate, and acrylate redispersible latex powder according to the mass ratio of 5:1:0.3:0.5:0.2, and then add the mixture to the core material system In, stir and mix evenly, the mass ratio of described mixture and core material is 1:1, the mixture that forms adopts decompression distillation to remove ethanol again, can obtain liposome film;

[0032] S3: Ultrasonic di...

Embodiment 2

[0034] A kind of method utilizing plant essential oil to prepare liposome microcapsule long-acting mosquito repellent ointment, comprises the steps:

[0035] S1: Dissolve p-menthane-3,8-diol and Java citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:1 Carry out ultrasonic emulsification with polyethylene glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 2.5% of Javanese citronella quality;

[0036] S2: Soybean lecithin, cholesterol, squash gum, propylene glycol alginate, and ethylene-vinyl acetate redispersible latex powder are made into a mixture according to the mass ratio of 8:1.5:0.5:1:0.2, and then the mixture is added to In the core material system, stir and mix evenly, the mass ratio of the mixture and the core material is 1:1.2, and the formed mixture is then decompressed to remove ethanol to obtain the liposome membrane;

[0037] S3: T...

Embodiment 3

[0039] A method utilizing plant essential oils to prepare liposome microcapsules long-acting mosquito repellent ointment, comprising the steps of:

[0040]S1: Dissolve p-menthane-3,8-diol and Javanese citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:3 Carry out ultrasonic emulsification with Polyethylene Glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 1.2% of Javanese citronella quality;

[0041] S2: Soybean lecithin, cholesterol, squash gum, propylene glycol alginate, and ethylene-vinyl acetate redispersible latex powder are made into a mixture according to the mass ratio of 10:2:0.1:0.6:0.3, and then the mixture is added to In the core material system, stirring and mixing are uniform, the mass ratio of the mixture and the core material is 1:1.5, stirring and mixing are uniform, and the formed mixture is then decompressed to remove ethanol t...

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Abstract

The invention discloses a method for preparing liposome microcapsules long-acting mosquito repellent ointment by utilizing plant essential oils, comprising p-menthane-3,8-diol yellow oil and Javanese citronella oil in a mass ratio of 2:1 Mix evenly and dissolve in absolute ethanol, then add sulfonated succinate salt castor oil and polyethylene glycol (600) dilaurate emulsifier for ultrasonic emulsification, and make a core material system; then soybean lecithin, cholesterol , seaweed gum, propylene glycol alginate, and redispersible latex powder are stirred into the core material system, stirred evenly, and the solvent is removed to obtain a liposome membrane; the liposome membrane is ultrasonically dispersed into a PBS buffer solution system with polyvinylpyrrolidone During, filter, collect filtrate, freeze-dry processing, form mosquito repellent ointment. The mosquito repellent ointment made by this method has a good mosquito repellent effect and double effects of moisturizing the skin, can well prevent the volatilization of essential oils, and has no toxic and side effects on people and the environment; the materials and processes used are more in line with environmental protection and health requirements.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for preparing liposome microcapsule long-acting mosquito repellent ointment by using plant essential oil. Background technique [0002] The main components of lemon eucalyptus oil are citronellal, neoisopulegol, isopulegol, citronellol, citronellyl acetate, and β-caryophyllene; Java citronella oil mainly contains citronellal, citronella Leaf alcohol, β-citronellol and elemol and other ingredients have good analgesic, antispasmodic, antibacterial, and antioxidant capabilities. Most of the water phase in the lemon eucalyptus extraction process is directly discharged into the environment, and has not been rationally developed and utilized, resulting in a waste of resources. There is a certain content in it, and it has a good mosquito repellent effect, and has no toxic and side effects on people and the environment. [0003] Javanese Citronella Oil Contains Citronellal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N65/44A01N31/06A01N25/28A01P17/00
CPCA01N65/44A01N31/06A01N25/28A01N65/00Y02A50/30
Inventor 谷瑶杨漓李桂珍
Owner GUANGXI FORESTRY RES INST
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