Method for establishing a fingerprint spectrum of traditional Chinese medicine oral preparation and fingerprint spectrum thereof

Abstract

The invention relates to the technical field of medicine detection, in particular to a method for establishing a fingerprint spectrum of a traditional Chinese medicine oral preparation and the fingerprint spectrum thereof, and the method comprises the following steps: S1, preparing a test solution: selecting different batches of dryness-clearing lung-rescuing decoction particle samples, precisely weighing, placing in a container, precisely adding water, ultrasonically dissolving, cooling, filtering, extracting filtrate by using ethyl acetate, mixing the ethyl acetate, evaporating to dryness, adding a methanol solution into residues, transferring into a measuring flask, adding methanol to dilute to a scale, shaking uniformly, filtering, and taking a subsequent filtrate to obtain a finished product. and S2, preparation of a reference substance solution: taking liquiritin, caffeic acid, iso-dendrobiin and isoliquiritin, adding methanol to dissolve, and preparing a solution containing 50 [mu]g of reference substances per 1ml as the reference substance solution. The fingerprint spectrum established by adopting the establishment method of the fingerprint spectrum can comprehensively characterize information of five medicinal materials including mulberry leaves, liquorice, ginseng, fried black sesame and honey loquat leaves in a prescription, and more comprehensively reflect the medicine quality.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for establishing fingerprints of oral preparations of traditional Chinese medicines and the fingerprints thereof. Background technique [0002] Qingzao Jiufei Decoction has a wide range of clinical applications, involving cough, hemoptysis, pulmonary fistula, sore throat, dermatological diseases such as hyperhidrosis, pruritus, constipation, watery urine syndrome, fistula and other diseases. Lung diseases such as cough and hemoptysis accounted for the main part. From the perspective of modern medicine, Qingzao Jiufei Decoction can be used in various clinical departments such as internal medicine, ENT, and dermatology. The most common one is to treat respiratory diseases. There is already a Qingzao Jiufei Decoction that can be prescribed for its symptoms, but It is made of nine traditional Chinese medicines including frost mulberry leaves, gypsum, Ophiopogon japon...

AI Technical Summary

Problems solved by technology

However, the chemical properties of different medicinal components of this product are quite different, and the medicinal flavor identified by a fingerprint is relatively small. However, due to the uneven quality of Chinese medicinal materials and the complexity of the components, it is difficult for existing analysis methods to fully reflect the quality of medicinal materials. The content of the drug standard of Zaojiufei Decoction basically only controls one or two index components, a

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