A detection system for chiral compounds
A technology for chiral compounds and detection systems, which can be used in measurement devices, the size/direction of magnetic fields, and material analysis by optical means, etc. problem, to achieve the effect of simple operation, easy on-site detection and accurate results
Active Publication Date: 2022-04-08
TONGJI UNIV
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Problems solved by technology
Spectral methods are mostly implemented by using the optical activity of chiral compounds (that is, the property of deflecting polarized light), which is difficult to quantify and is easily interfered by stray light
And the spectroscopy requires the use of very precise optical devices, which poses a great challenge to the manufacturing process
Chromatographic methods mainly rely on the different adsorption capacities of chromatographic column fillers for chiral compounds with different configurations for separation and content detection. However, the scope of application of chromatographic methods is limited, and commonly used chiral chromatographic columns can only be applied to some Chiral compounds with its adsorption characteristics cannot detect compounds with too large molecular weight, too small molecular weight or no polarity
[0004] In addition, in the above-mentioned existing detection systems, the equipment of the spectral detection system is more complicated and hardly portable, while the equipment of the chromatographic system needs to include mobile phase devices and detection devices, etc., and is not portable. Therefore, the existing The detection of chiral compounds needs to be carried out in the laboratory, and the on-site detection of the samples to be tested cannot be realized
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Embodiment Construction
[0020] The specific implementation manners of the present invention will be described below in conjunction with the accompanying drawings.
[0021]
[0022] figure 1 It is a schematic diagram of the composition of the detection system in Embodiment 1 of the present invention.
[0023] Such as figure 1 As shown, this embodiment provides a chiral compound detection system (hereinafter referred to as the detection system) 100, including a base material 10, a stage 20, a laser generator and a magnetic field strength detection device (not shown in the figure).
[0024] In this embodiment, the laser generating device is a laser generator, and the magnetic field strength detecting device is a Gauss meter.
[0025] The base material 10 is a gold nanohelical fiber array arranged on a substrate made of a material that does not have optomagnetic responsiveness. The gold nanohelical fiber array has such characteristics: 1) gold has optomagnetic responsiveness, and when laser irradiati...
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Abstract
The invention provides a detection system for chiral compounds, which is characterized in that it comprises: a base material for carrying a sample to be tested; a laser generating device for performing laser irradiation on the base material on which the sample to be tested is loaded; And a magnetic field intensity detection device for detecting the magnetic field intensity after laser irradiation, wherein the base material is made of a chiral optomagnetic responsive material, and the laser light generated by the laser generating device is non-polarized light. Compared with the chiral compound detection system in the prior art, the detection system of the present invention has the advantages of simple operation, accurate result, easy on-site detection and the like.
Description
technical field [0001] The invention relates to a detection system for chiral compounds. Background technique [0002] Chiral compounds refer to a class of compounds that have the same molecular structure but are mirror images of each other in configuration. In the field of pharmaceutical and chemical engineering, a pair of chiral compounds that are mirror images of each other usually have different properties. For example, thalidomide has two enantiomer configurations, S and R, which are mirror images of each other, and the R form has central sedative properties. However, the S type has a strong teratogenic effect. Therefore, in the R&D and production process involving chiral compounds, the distinction between enantiomers and content detection are crucial steps. [0003] In the prior art, the analysis and detection systems for chiral compounds mainly include two types, ie spectroscopic and chromatographic. Spectroscopic methods are mostly implemented by utilizing the opt...
Claims
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IPC IPC(8): G01N27/72G01N21/17G01R33/032
CPCG01N27/72G01N21/1717G01R33/032G01N2021/1727
Inventor 车顺爱刘泽栖段瑛滢
Owner TONGJI UNIV