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Colorectal cancer risk assessment model and system

A risk assessment model, colorectal cancer technology, applied in the field of biomedicine, can solve the problems of losing the chance of surgical cure, poor chemotherapy effect, poor overall prognosis, etc., to achieve disease and normal, high diagnostic sensitivity and specificity , the effect of high prediction accuracy

Pending Publication Date: 2021-07-23
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of colorectal cancer is still dominated by surgery, supplemented by radiotherapy and chemotherapy. However, due to the hidden early clinical symptoms of the disease, most patients are diagnosed at an advanced stage when they are diagnosed. Such patients have lost the chance of surgical cure. Poor, and thus overall poorer prognosis

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  • Colorectal cancer risk assessment model and system
  • Colorectal cancer risk assessment model and system
  • Colorectal cancer risk assessment model and system

Examples

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Embodiment 1

[0137] Example 1 Construction of colorectal cancer risk assessment model

[0138] 1. Data source and acquisition

[0139] All the data for constructing the colorectal cancer risk assessment model were downloaded from the TCGA and NCBI-SRA databases. The expression files of colorectal cancer and adjacent cancers were downloaded from the TCGA database, and the raw data of intestinal polyps were downloaded from the NCBI-SRA database. A total of 443 samples of colorectal cancer cases, 31 samples of intestinal polyps, and 72 normal samples were selected from the retrieval, and a total of 546 sample data were used for further screening and quality control.

[0140] 2. Raw data processing

[0141] Use fastp software for joint processing and quality control to obtain cleandata. The steps include:

[0142] a. Joint treatment

[0143] Use the double-end sequence automatic detection mode of fastp software to process the adapter;

[0144] b. Data pruning and quality control

[0145] ...

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Abstract

The invention relates to a colorectal cancer risk assessment model and system, the risk assessment model comprises four sub-modules, the system is embedded with an intestinal polyp risk assessment model developed by machine learning, whether a subject suffers from a disease or has a disease risk is judged according to the risk assessment model by receiving sequencing information from the subject, and the risk assessment model is used for determining whether the subject suffers from the disease or not, and suggestions are further provided for treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a risk assessment model and system for colorectal cancer. Background technique [0002] Colorectal cancer (CRC) is one of the common malignant tumors that seriously endanger human health (Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67( 3): 177-193.). According to statistics from the National Cancer Registry of China, there were 376,300 new colorectal cancer patients in my country in 2015, accounting for 8.77% of the total, ranking fifth in the incidence of malignant tumors in the country, second only to lung cancer, gastric cancer, esophageal cancer, and liver cancer. The number of deaths was 191,000, ranking fifth among all cancer deaths in the country (Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015[J]. CA: a cancer journal forclinicians, 2016, 66(2) :115-132.). Although the incidence of colorectal cancer...

Claims

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Application Information

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IPC IPC(8): G16B40/20G16B20/00G16C20/50
CPCG16B20/00G16B40/20G16C20/50
Inventor 杨承刚李雨晨
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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