Preparation method of a flexible hydrogel and its application in high-performance medical protective equipment

A hydrogel, high-performance technology, applied in applications, protective clothing, clothing, etc., can solve the problems of mask-skin elastic modulus mismatch, uneven spatial pressure distribution, facial skin friction damage, etc., to achieve soft texture, The effect of increasing the contact area and reducing damage

Active Publication Date: 2022-05-24
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Mask leakage and facial friction damage are mainly due to the following reasons: (1) The elastic modulus of the mask and the skin does not match; the elastic modulus of the mask fabric is greater than that of the skin tissue (the elastic modulus E of the non-woven fabric and the skin tissue are respectively 27.7MPa and 0.42-0.85MPa), the resulting elastic modulus does not match, and when the mask-skin is relatively sliding, it is easy to cause friction damage to the facial skin; (2) the spatial pressure distribution of the facial skin is uneven; Studies have shown that when wearing an N95 medical mask, the contact pressure at the bridge of the nose is the largest (up to 0.11MPa), and the deformation in the middle of the cheek is the largest (up to 0.93mm); the bridge of the nose where the pressure is the highest is also the most severely worn area when wearing the mask; ( 3) The fit is not tight in the exercise state; when the mask is worn, the elastic bandage only provides pressure for the fit between the mask and the face, but the non-woven material of the inner layer of the mask has no adhesion to the skin; medical staff need frequent Communicate accurately with patients or colleagues; due to elastic modulus mismatch and uneven pressure distribution, frequent relative movements of "mask-skin" caused by facial muscle activities will cause frictional injuries at the bridge of the nose and cheeks of medical staff
Therefore, in order to eliminate the problem of poor sealing of the mask due to the formation of gaps after wearing it and the discomfort of the facial skin caused by wearing it for a long time, it is necessary to design a new type of mask with good sealing performance and less oppression on the facial skin.

Method used

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  • Preparation method of a flexible hydrogel and its application in high-performance medical protective equipment
  • Preparation method of a flexible hydrogel and its application in high-performance medical protective equipment
  • Preparation method of a flexible hydrogel and its application in high-performance medical protective equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Flexible Hydrogel

[0036] Include the following steps:

[0037](1) Using N-MBEDA and diisocyanate monomer, Sn(Oct) 2 As a catalyst, a condensation polymerization method is used to prepare a water-soluble polyurethane matrix PU-1, and then the reaction between the tertiary amine of PU-1 and ethyl bromide is used to prepare a polyurethane polymer PU-1(+) with constant cationic charge, specifically: :

[0038] According to the following chemical reaction formula, under the protection of dry nitrogen, the vacuum dehydrated N-MBEDA and diisocyanate monomers were poured into a 250 mL volume of 250 mL with reflux condensation at a molar ratio of 1:1 In a three-necked flask with a tube and a thermometer, take 2g Sn(Oct) 2 As a catalyst, N-MBEDA was used as a chain extender, mechanically stirred at 80 °C for 2 hours, and then heated to 85 °C for 2 hours to prepare a water-soluble polyurethane matrix (PU-1); then 0.1 mol of ethyl bromide was added. ,...

Embodiment 2

[0047] Example 2 Preparation of flexible hydrogels

[0048] Include the following steps:

[0049] Steps (1) and (2) are with embodiment 1;

[0050] (3) Using DMF (dimethylformamide) as a solvent, prepare PU-1(+) aqueous solution (concentration of 0.01mol) and PU-2(-) aqueous solution (concentration of 0.01mol), respectively, mix PU-1 ( The +)) aqueous solution and the PU-2(-)) aqueous solution were stirred at a volume ratio of 1:1 using a mechanical stirring bar for 30 min, and then the system temperature was kept at 30 °C for 6 h to obtain a liquid polyurethane hydrogel. Introduce the liquid polyurethane hydrogel into the mold, slowly add water along the inner wall of the mold, soak for a period of time, so that most of the solvent in the hydrogel is soaked out, and then vacuum dry to obtain a formed solid polyurethane hydrogel, that is, a flexible hydrogel. glue.

Embodiment 3

[0051] Example 3 Preparation of Flexible Hydrogel

[0052] Include the following steps:

[0053] Steps (1) and (2) are with embodiment 1;

[0054] (3) Using DMF (dimethylformamide) as a solvent, PU-1(+) aqueous solution (concentration of 0.1 mol) and PU-2(-) aqueous solution (concentration of 0.1 mol) were prepared respectively, and PU-1 ( The +)) aqueous solution and the PU-2(-)) aqueous solution were stirred at a volume ratio of 1:1 using a mechanical stirring bar for 30 min, and then the system temperature was kept at 30 °C for 6 h to obtain a liquid polyurethane hydrogel. Introduce the liquid polyurethane hydrogel into the mold, slowly add water along the inner wall of the mold, soak for a period of time, so that most of the solvent in the hydrogel is soaked out, and then vacuum dry to obtain a formed solid polyurethane hydrogel, that is, a flexible hydrogel. glue.

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Abstract

The invention belongs to the technical field of medical protection, and specifically relates to a preparation method of a flexible hydrogel and its application in high-performance medical protective equipment. The invention uses diol monomers, diisocyanate monomers and other raw materials to prepare hydrogels with constant cations. Charged polyurethane polymer PU‑1(+) and water-soluble polyurethane material PU‑2(‑) modified with negatively charged carboxylic acid, and then use the positive and negative charges of PU‑1(+) and PU‑2(‑) A flexible hydrogel was prepared by mutual attraction. The flexible hydrogel can be prepared as a hydrogel inner fitting layer on the edge of the inner layer of the mask body, because the inner fitting layer of the hydrogel has good adhesion to the skin and the mask fabric, and is compatible with the elastic mold of the skin. The amount is similar and has good biocompatibility, so it can fit closely with the facial skin and enhance the overall protective effect of the mask. At the same time, it can effectively reduce the pain caused by the edge fixing strip tightening the face and causing the face to be stressed.

Description

technical field [0001] The invention belongs to the technical field of medical protection, and in particular relates to a preparation method of a flexible hydrogel and its application in high-performance medical protection equipment. Background technique [0002] Masks are an important protective tool in epidemic prevention work. Ideally, the mask can fit closely with the face, and the multi-layer structure of the medical mask can effectively filter the fine droplets or solid particles that carry pathogenic bacteria suspended in the air. However, affected by the difference in elastic modulus between the mask and the skin and the complex three-dimensional contour of the face, the pressure and deformation of the facial skin are not uniformly distributed in the actual use of the mask, resulting in the mask and the face not being able to fit closely. . At the same time, affected by the differences in individual facial morphology, there is a common gap between the mask and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L75/04A41D13/11A41D27/24C08G18/32C08G18/34
CPCC08J3/075C08G18/3275C08G18/3206C08G18/348A41D13/1176A41D27/24A41D2400/82C08J2375/04C08J2475/04
Inventor 李哲朱奥旬吴大林
Owner SUN YAT SEN UNIV
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