Application of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning

A risk stratification, mg7-ag technology, applied in the application field of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning, to achieve good predictive value, high predictive efficiency, and avoidance of abnormality. qualitative effect

Active Publication Date: 2021-08-10
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, these studies have not been able to accurately predict the high-risk gastrointestinal metaplasia patients whose final evolution outcome is gastric cancer among many patients with gastrointestinal metaplasia

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  • Application of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning
  • Application of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning
  • Application of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning

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Embodiment Construction

[0040] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments, and the described embodiments are explanations of the present invention, rather than limiting the protection scope of the present invention.

[0041] Through literature review and analysis, the present invention screened out gastric cancer-associated antigen MG7-Ag, human telomerase reverse transcriptase (human telomerase reverse transcriptase, hTERT), trefoil factor 2 (Trefoil factor family 2, TFF2) Molecules of predictive value for metaplastic progression to gastric cancer. The present invention detects the expression levels of MG7-Ag, hTERT, and TFF2 in gastrointestinal metaplasia samples with different outcomes through the follow-up of a cohort of patients with gastrointestinal metaplasia. After analysis, it is found that MG7-Ag and hTERT are expressed at a low level Or the gastrointestinal metaplasia tissue that does not express TFF2 has th...

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Abstract

The invention discloses an application of MG7-Ag, hTERT and TFF2 expression analysis in intestinal metaplasia risk stratification and gastric cancer early warning. Immunohistochemical staining is adopted to carry out expression level detection on MG7-Ag, hTERT and TFF2 in endoscopic biopsy tissue specimens of gastrointestinal metaplasia patients with different outcomes; a Logistic regression model is constructed by using the expression level semi-quantitative results of the three molecules of a modeling queue; model internal verification and external verification are carried out in the modeling queue and a verification queue; and gastrointestinal metaplasia risk stratification and gastric cancer early warning are carried out by using the constructed model. According to the invention, heterogeneity of individuals and people can be avoided, clinical application is more convenient, and a new idea is provided for gastric cancer prevention based on gastrointestinal metaplasia intervention.

Description

technical field [0001] The invention belongs to the field of tumor medicine, and relates to a joint prediction model based on the expression levels of MG7-Ag, hTERT and TFF2, in particular to the detection of MG7-Ag, The expression of hTERT and TFF2 was detected, and a model for risk stratification of gastrointestinal metaplasia and early warning of gastric cancer was constructed. Background technique [0002] Gastric cancer is one of the common malignant tumors, and its morbidity and mortality are still high in various regions of the world, especially in East Asia. The Correa model reveals the law of the development of gastric cancer, especially intestinal type gastric cancer. Studies have confirmed that whether there is Helicobacter pylori (H. pylori) infection or not, gastric mucosal intestinal metaplasia (Intestinal metaplasia, IM) is an important risk factor for gastric cancer. [0003] Current methods for risk stratification of gastric precancerous lesions include th...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/573G16B40/00
CPCG01N33/57446G01N33/57484G01N33/573G16B40/00Y02A90/10
Inventor 时永全吴斯然
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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