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Methods of treating viral pneumonia

A coronavirus, disease technology, applied in the field of medical use

Pending Publication Date: 2021-08-13
SHANGHAI HUILUN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the severe patients who progressed to ARDS in this epidemic, there is currently no clinically targeted treatment drug, so it is urgent to provide a treatment or improve the novel coronavirus pneumonia (Novelcoronavirus pneumonia, referred to as 2019-nCoV or NCP or COVID-2019) Drugs for the treatment of patients with acute lung injury or acute respiratory distress syndrome

Method used

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  • Methods of treating viral pneumonia
  • Methods of treating viral pneumonia
  • Methods of treating viral pneumonia

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0062] The present invention adopts the method disclosed in the prior art to prepare formula I or its sodium salt, such as the method disclosed in EP0539223A1 and the preparation method in EP0347168B1. The preparation used in the clinical experiment of the present invention can be prepared according to the method disclosed in CN1263736C, or according to the preparation method disclosed in CN104107172B.

[0063] Meet the diagnostic criteria for new coronavirus pneumonia:

[0064] Areas outside of high-risk areas:

[0065] (1) Suspected cases

[0066] Comprehensive analysis combined with the following epidemiological history and clinical manifestations:

[0067] 1. Epidemiological history

[0068] (1) Travel history or residence history in high-risk areas and surrounding areas, or other communities with case reports within 14 days before fever;

[0069] (2) Have a history of contact with a new type of coronavirus infection (positive nucleic acid test) within 14 days before t...

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Abstract

The invention provides a method for treating viral pneumonia, and particularly relates to application of N-{2-[4-(2, 2-dimethyl propionyloxy) benzenesulfonylamino] benzoyl} amino acetic acid or pharmaceutically acceptable salt thereof in preparation of a medicine for treating or improving acute lung injury or acute respiratory distress syndrome of a novel coronavirus pneumonia patient. According to the method, lung inflammation can be effectively inhibited, the lung injury condition is improved, and for a patient, the duration of ventilator use and ICU stay can be obviously shortened.

Description

technical field [0001] The present invention relates to the field of medical application, in particular to a kind of N-{2-[4-(2,2-dimethylpropionyloxy)benzenesulfonylamino]benzoyl}aminoacetic acid or its pharmaceutically acceptable Use of salt in the preparation of medicines for treating or improving acute lung injury or acute respiratory distress syndrome in patients with novel coronavirus pneumonia. Background technique [0002] Chemical name: N-{2-[4-(2,2-dimethylpropionyloxy)benzenesulfonylamino]benzoyl}aminoacetic acid, with the following chemical structure: [0003] [0004] The original research company is Japan Ono Pharmaceutical Co., Ltd., and the indication is to improve acute lung injury (ALI) accompanied by systemic inflammatory response syndrome (SIRS). [0005] Experimental research in vitro shows that the compound of formula I of the present invention and its pharmaceutically acceptable salts can strongly inhibit the activity of neutrophil elastase derived...

Claims

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Application Information

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IPC IPC(8): A61K31/222A61P31/14A61P11/00
CPCA61K31/222A61P11/00A61P31/14
Inventor 李文华汤靖雯李军王丽
Owner SHANGHAI HUILUN BIOLOGICAL TECH CO LTD