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A modified zirconia ceramic with a surface composite bioactive substance and its preparation method

A technology of biologically active substances, zirconia ceramics, applied in the field of dental restoration medical materials, to achieve the effect of improving biological activity, improving biological activity, and good biological activity

Active Publication Date: 2022-05-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings and deficiencies that the conventional bio-modified zirconia dental ceramics in the prior art cannot simultaneously have excellent biological activity and high mechanical strength, the purpose of the present invention is to provide a modified zirconia ceramic with a surface composite bioactive substance and its preparation method

Method used

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  • A modified zirconia ceramic with a surface composite bioactive substance and its preparation method
  • A modified zirconia ceramic with a surface composite bioactive substance and its preparation method
  • A modified zirconia ceramic with a surface composite bioactive substance and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0060] (1) Preparation of calcium-magnesium-silicon biologically active sol: add 10g of ethyl orthosilicate, 20g of calcium nitrate, and 30g of magnesium nitrate in 50g of deionized water, mix well to obtain a mixed solution, adjust the pH of the mixed solution to 8.0, and make it happen Hydrolysis and polycondensation reaction (reaction time is 12h) to form calcium magnesium silica sol;

[0061] (2) The yttria-stabilized zirconia powder is press-molded, the pressure of the press-molding is 220MPa, and the press-molding time is 2min to prepare a green zirconia ceramic body, and the pre-sintering treatment is carried out under the condition that the temperature is raised to 500°C, The pre-sintering treatment time is 2h, and the heating rate is 10°C / min to obtain a zirconia ceramic pre-sintered body;

[0062] (3) Preparation of zirconia suspension: polyethyl acrylate microspheres, polyvinyl alcohol, polyacrylic acid, deionized water and zirconia powder are mixed according to the...

Embodiment 2

[0071] (1) Preparation of calcium magnesium silicon bioactive sol: add 10g ethyl orthosilicate, 20g calcium nitrate, 30g magnesium citrate in 50g deionized water, mix well to obtain a mixed solution, adjust the pH of the mixed solution to 8.0, and make it happen Hydrolysis and polycondensation reaction (reaction time is 24h) to form calcium magnesium silica sol;

[0072] (2) The yttria-stabilized zirconia powder is press-molded, the pressure of press-molding is 100MPa, and the time of press-molding is 30min, to prepare a green zirconia ceramic body, and pre-sintering is carried out under the condition that the temperature is raised to 500°C, The pre-sintering treatment time is 2h, and the heating rate is 2°C / min to obtain a zirconia ceramic pre-sintered body;

[0073] (3) Preparation of zirconia suspension: polyethyl acrylate microspheres, polyvinyl alcohol, polyacrylic acid, deionized water and zirconia powder are mixed according to the mass ratio of 10:10:2:53:25, and the mi...

Embodiment 3

[0081] (1) Preparation of calcium-silicon-phosphorus bioactive sol: add 31g of ethyl orthosilicate, 29g of calcium nitrate, and 20g of sodium phosphate in 20g of deionized water, mix well to obtain a mixed solution, adjust the pH of the mixed solution to 8.0, and make it hydrolyzed Polycondensation reaction (reaction time is 24h) to form calcium-silicon-phosphorus sol;

[0082] (2) The yttria-stabilized zirconia powder is press-molded, the pressure of press-molding is 180MPa, and the time of press-molding is 10min, to prepare a zirconia ceramic green body, and pre-sintering is carried out under the condition that the temperature is raised to 500°C, The pre-sintering treatment time is 2h, and the heating rate is 5°C / min, to obtain a zirconia ceramic pre-sintered body;

[0083] (3) Preparation of zirconia suspension: polyethyl acrylate microspheres, polyvinyl alcohol, polyacrylic acid, deionized water and zirconia powder are mixed according to the mass ratio of 10:10:2:53:25, an...

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Abstract

The invention discloses a modified zirconia ceramic whose surface is composited with bioactive substances and a preparation method thereof. The method comprises: preparing calcium magnesium silicon or calcium silicon phosphorus bioactive sol; preparing zirconia suspension; preparing zirconia ceramics with a porous surface layer; and placing the zirconia ceramics with a porous surface layer in calcium through a negative pressure infiltration process. Magnesium-silicon or calcium-silicon-phosphorus bioactive sol is used to infiltrate the bioactive sol into the porous surface layer, and heat treatment is carried out after drying to obtain the ceramic. In the present invention, calcium-magnesium-silicon or calcium-silicon-phosphorus biologically active substances are attached to the pores of the porous surface layer of zirconia, endowing zirconia ceramics with high biological activity, and the porous surface layer is combined with zirconia ceramics and fired simultaneously to solve the problem of surface activity. The problem of poor bonding strength between the layer and the zirconia matrix material interface; while the bioactive material only penetrates into the porous surface layer, and the internal matrix still maintains high density after sintering, and the mechanical properties of the material are not significantly affected.

Description

technical field [0001] The invention relates to the field of dental restoration medical materials, in particular to a modified zirconia ceramic with surface composite biological active substances and a preparation method thereof. Background technique [0002] Titanium and titanium alloy implants in metal implants have been widely used in clinical treatment of tooth loss caused by dental caries, periodontitis and dental trauma. However, there are also problems such as blackening of titanium metal caused by gingival recession and allergy caused by the release of toxic ions. Zirconia ceramics have good biocompatibility and chemical stability, excellent mechanical properties and unique aesthetic effects and become a dental restoration material with good clinical application prospects. As an inert material, zirconia ceramics have no biological activity. When implanted in the body, the surrounding fibrous tissue will hinder the integration of the implant and the surrounding bone ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/818A61K6/71A61K6/74A61K6/76C04B38/06C04B35/48C04B35/622C04B35/624
CPCC04B38/067C04B35/48C04B35/622C04B35/624A61K6/818A61K6/76A61K6/74A61K6/71C04B2235/3208C04B2235/3206C04B2235/447C04B2235/6562C04B2235/6567C04B2235/96
Inventor 叶建东秦艳萍张文民
Owner SOUTH CHINA UNIV OF TECH
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