Application of SPDEF gene inhibitor in preparation of medicine for enhancing sensitivity of lung mucus adenocarcinoma cells to cis-platinum
A technique for gene suppression and mucinous adenocarcinoma, applied in drug combinations, active ingredients of hydroxyl compounds, antineoplastic drugs, etc., to achieve the effects of inhibiting expression, promoting apoptosis, and enhancing sensitivity
Active Publication Date: 2021-08-27
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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There is no report on the application of resveratrol in mucinous adenocarcinoma of the lung, so we conducted further research on whether resveratrol can be used as a potential drug for the treatment of mucinous adenocarcinoma of the lung, in order to provide a basis for the treatment of mucinous adenocarcinoma of the lung. new treatment options
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[0038] The technical solutions of the present invention will be further described below in conjunction with the drawings and embodiments. The experimental method that does not indicate specific condition in the embodiment, generally according to conventional conditions, such as people such as Sambrook, molecular cloning: the condition described in the laboratory handbook (NewYork: Cold Spring Harbor Laboratory Press, 1989), or according to manufacturer's suggested conditions.
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The invention discloses an application of an SPDEF gene inhibitor in the preparation of a medicine for enhancing the sensitivity of lung mucous adenocarcinoma cells to cis-platinum. The sensitivity of patients to cis-platinum treatment can be enhanced by inhibiting the expression quantity of SPDEF genes in the lung mucous adenocarcinoma cells of the patients. The invention also discloses a combined anti-pulmonary adenocarcinoma pharmaceutical composition. The pharmaceutical composition comprises the SPDEF gene inhibitor and the cis-platinum, and compared with the single use of the cis-platinum as an anti-cancer drug, the combined use of the SPDEF gene inhibitor and the cis-platinum can further promote the apoptosis of pulmonary adenocarcinoma cells.
Description
technical field [0001] The invention relates to the field of biotechnology, in particular to the application of an SPDEF gene inhibitor in the preparation of drugs for enhancing the sensitivity of lung mucinous adenocarcinoma cells to cisplatin. Background technique [0002] Lung cancer is one of the malignant tumors with the highest incidence and mortality rate, which seriously threatens human health. Among the types of lung cancer, non-small cell lung cancer (NSCLC, including lung adenocarcinoma, lung squamous cell carcinoma and large cell carcinoma) is the most common pathological type of lung cancer, accounting for more than 70% of the total number of lung cancers, and the proportion of lung adenocarcinoma is Upward trend. Mucinous adenocarcinoma of the lung is a distinct subtype of lung adenocarcinoma, accounting for approximately 5% of all lung adenocarcinomas. Unlike other lung adenocarcinomas, the treatment options for mucinous adenocarcinoma of the lung are limite...
Claims
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IPC IPC(8): A61K45/06A61K31/05A61K33/243A61K31/7088A61P11/00A61P35/00C12Q1/6886
CPCA61K45/06A61K31/05A61K33/243A61K31/7088A61P11/00A61P35/00C12Q1/6886C12Q2600/106C12Q2600/158A61K2300/00Y02A50/30
Inventor 倪振华王雄彪林玉华
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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