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Antigen peptide related to esophageal cancer driver gene mutation and application thereof

A driver gene, esophageal cancer technology, applied in the field of biomedicine, can solve the problems of failure to form effects, superior therapeutic agents, etc., and achieve the effect of inhibiting tumor cell growth, good clinical transformation and disease prevention prospects

Active Publication Date: 2021-08-31
上海保亿仁生物医药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, because technology requires multidisciplinary, high-tech, and multi-platform collaborative research, antigenic peptides related to mutations in esophageal cancer driver genes have not been systematically discovered and a relatively complete peptide library has not been established, so it has not yet formed a superior effect. therapeutic agent

Method used

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  • Antigen peptide related to esophageal cancer driver gene mutation and application thereof
  • Antigen peptide related to esophageal cancer driver gene mutation and application thereof
  • Antigen peptide related to esophageal cancer driver gene mutation and application thereof

Examples

Experimental program
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Embodiment Construction

[0018] Below, in conjunction with specific embodiment, the present invention is described further:

[0019] Antigen peptides related to mutations in esophageal cancer driver genes used in the examples are shown in Table 1:

[0020] Table 1 Antigen peptide sequences related to esophageal cancer driver gene mutations

[0021]

[0022]

[0023] The operation for the establishment of antigenic peptide-specific CTL clones related to esophageal cancer driver gene mutations is as follows:

[0024] 10 from the same healthy donor 5 CD8 + T cells load 10 antigenic peptides associated with esophageal cancer driver mutations 4 Mo-DCs were stimulated twice at intervals of 1 week, and then passed autologous 10 5 Mitomycin C-treated PBMCs loaded with antigenic peptides associated with esophageal cancer driver gene mutations were stimulated once and screened by standard cytotoxicity assays.

[0025] T2 cells were loaded with 5uM antigenic peptides associated with esophageal cancer ...

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Abstract

The invention discloses an antigen peptide related to esophagus cancer driver gene mutation. Esophagus cancer driver genes are at least two of EPCAM, MUC1, GPC3, LRP1B, ERBB4 and PREX2; the sequence of the antigen peptide includes at least two of SEQ No.1-12; according to the application of the antigen peptide, the antigen peptide is used for inducing generation of specific cytotoxic T cell clone; the antigen peptide has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of esophagus cancer related driver gene mutation tumor cells, and has good treatment potential.

Description

technical field [0001] The invention relates to an antigenic peptide related to esophageal cancer driver gene mutation and application thereof, belonging to the technical field of biomedicine. Background technique [0002] Esophageal cancer is a common digestive tract tumor, and about 300,000 people die from esophageal cancer every year in the world. Its morbidity and mortality vary widely from country to country. my country is one of the areas with a high incidence of esophageal cancer in the world, with an average of 150,000 deaths per year. [0003] Conventional treatment methods for esophageal cancer are generally: surgical resection; radiotherapy, which can improve the long-term survival rate but has many complications and unsatisfactory curative effect; chemotherapy: sometimes can improve the curative effect, or relieve symptoms and prolong the survival period of patients with esophageal cancer , but regularly check blood and liver and kidney function, and pay attent...

Claims

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Application Information

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IPC IPC(8): C07K14/705C07K14/82C12N9/12C12N5/0783A61K39/00A61P35/00
CPCC07K14/4748C12N9/12C12N5/0638A61K39/00117A61K39/001102A61P35/00C12Y207/10001C12N2501/58C12N2501/999C12N2501/727A61K2039/80A61K39/001174A61K39/001166A61K39/001156A61K39/0011
Inventor 郝冰娜赵环蔡睿罗夫辛克纳吉张积仁李许峰
Owner 上海保亿仁生物医药有限公司
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