Lactobacillus gasseri and application thereof in treatment of peptic ulcer
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A technology of Lactobacillus gasseri and microbial agent, applied in the field of microorganisms
Pending Publication Date: 2021-09-07
孙长春
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However, the combination of L. gasseri CECT5714 and B. gallineri CECT5711 stimulated NK cells and increased secreted IgA levels, but this effect was not observed for either L. gasseri ATCC 33323 or L. gasseri TMC0356 (specifically 参见Olivares M Díaz-Ropero MAP Gómez NLara-Villoslada F Sierra S Maldonado JA Martín R López-Huertas ERodríguez JM&Xaus J(2006a)Oral administration of two probiotic strains,Lactobacillusgasseri CECT5714 and Lactobacillus coryniformis CECT5711,enhances theintestinal function of healthy adults.Int J Food Microbiol 107:104–111. and Stoeker L Nordone S Gunderson S Zhang L Kajikawa A LaVoy A Miller MKlaenhammer TR & Dean GA (2011) Assessment of Lactobacillus gasseri as candidate oral vaccine vector. Clin Vaccine Immunol 18:1834–1844.)
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Embodiment 1
[0026] Screening and culture of the strain
[0027] A strain was screened from a healthy human intestinal strain, which has a 16SRNA sequence shown in SEQ ID NO: 1, which compares the sequence of sequence to the gene in genbank, the strain. It was identified as a Lactobacillus Gasseri. The inventors are named TTYS-839 in Lactobacillusgasseri.
[0028]Lactobacillus Gasseri TTYS-839 has been stored in the ordinary microbiological center of China's Microbial Square Safety Management Committee on July 2, 2020, and is divided into Lactobacillus Gasseri, deposit number. For the CGMCC No. 20178, the deposit address is the Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichen West Road, Chaoyang District, Beijing.
Embodiment 2
[0029] Example 2 Treatment of Grilumacillus TTYS-839 on gastric ulcer
[0030] The stomach ulcer animal model was constructed as a model animal and acetic acid wet application, and TTYS-839 treatment of gastric ulcer was studied.
[0031] 1, experimental animals
[0032] SD rats, male, 180-220g, purchased in Shenyang Pharmacology University Experimental Animal Center. Feeding environment: 22 ± 2 ° C, humidity is 45 ~ 65%, 12 h laterally alternate; free eating and drinking water.
[0033] 2, experimental method
[0034] (1) modeling
[0035] After the rat is adaptively raised for 7 days, the animal is not allowed to prevent water for 24 hours, and the ether is anesthetized to cut the abdominal cavity under the swing, and the stomach is pulled out of the abdominal cavity, and the amount of acetic acid is immersed with a diameter of 5mm. The sinus slurry film is applied three times, suture cut, and then three days after surgery.
[0036] (2) Group and administration
[0037] 48 were ...
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Abstract
The invention relates to the field of microorganisms, in particular to lactobacillus gasseri and application thereof in treatment of peptic ulcer. The lactobacillus gasseri TTYS-839 disclosed by the invention is preserved in the China General Microbiological Culture Collection Center on July 2, 2020, the taxonomic name is lactobacillus gasseri, the preservation number is CGMCC No.20178, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, Yard 1, West Beichen Road, Chaoyang District, Beijing. The invention also provides a microbial agent containing the lactobacillus gasseri TTYS-839, the microbial agent is fed to a gastric ulcer rat prepared by an acetic acid wet compress method, the ulcer area and the ulcer volume can be obviously reduced, and the microbial agent has an obvious treatment effect on gastric ulcer.
Description
Technical field [0001] The present invention relates to the field of microorganisms, and more particularly to a strang Lactobacillus and its application in the treatment of digestive ulcers. Background technique [0002] Digestive ulcers are common chronic diseases, which can occur in the vicinity of esophageal, stomach, duodenal, stomach-empty anastomosis, mainly in abdominal pain, chronic process, and periodic attack. This disease is due to H. spiral infection, long-term use of drugs, genetic susceptibility, stress, smoking, long-term mental tensions, etc., gastric acid, gastric protease erosion and mucosa have lost balance between defense capabilities, gastric acid And gastric proteases have a self-digestion to the mucosa. The current treatment is mainly acidic, eradicating Helicobacter spiral infection, ruthenium protects gastric mucosa, but patients often in recurrence-alleviating periodic episodes, severe bleeding, perforation, pylorial obstruction, even cancer, need new Th...
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