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Cannabinoid chewing gum with high intensity sweeteners

A high-intensity sweetener, chewing gum technology, applied in the field of cannabinoids and the alleviation or treatment of conditions with one or more cannabinoids, capable of addressing inability to properly handle delivery vehicles, impact on convenience, impact on cannabinoid delivery, etc. question

Pending Publication Date: 2021-09-07
诺狄更斯公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If abnormal features are the predominant sensation during application, convenience may be affected and, even more critically, cannabinoid delivery may be affected
Saliva production may be inhibited and delivery vehicle may not be properly processed

Method used

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  • Cannabinoid chewing gum with high intensity sweeteners
  • Cannabinoid chewing gum with high intensity sweeteners
  • Cannabinoid chewing gum with high intensity sweeteners

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0266] Gum base preparation

[0267] Twenty different water insoluble gum bases were prepared. Gum bases were prepared as described below. In the examples that follow, the specific composition of the gum bases (GB10 to GB29) is outlined.

[0268] Elastomers and elastomer plasticizers (PVA) were mixed together with fillers (calcium carbonate or talc) at 120°C in a mixer with a horizontally placed Z-arm for mixing. Note that PVA is used as an elastomeric plasticizer for the elastomer in the composition and is not in the form of the elastomer. In this context, PVA as elastomer plasticizer has special properties. For some comparative examples, another comparative polymer was added and mixed together with the elastomer and elastomer plasticizer.

[0269] The natural resin was added after the polymer had been mixed for about 30 minutes. After the polymers and natural resins have been softened in the composition, additional ingredients such as triacetin, emulsifiers, waxes, anti...

Embodiment 2

[0274] Various gum base preparations

[0275]

[0276] Table 1A: Gum base composition, PVA = polyvinyl acetate (Vinnapas B 1.5 sp., supplied by Wacker); PIB = polyisobutylene (Oppanol B12, supplied by BASF); BR = butyl rubber (isobutylene-isoprene Copolymer); Nat. resin = glycerides of hydrogenated gum rosin; Veg. fat = vegetable fat.

Embodiment 3

[0278] Various gum base preparations

[0279]

[0280] Table 1B: Gum base composition, PVA = polyvinyl acetate (Vinnapas B 1.5 sp., supplied by Wacker); PIB = polyisobutylene (Oppanol B12, supplied by BASF); BR = butyl rubber (isobutylene-isoprene Copolymer); Nat. resin = glycerides of hydrogenated gum rosin; Veg. fat = vegetable fat.

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Abstract

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum comprising water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum comprising one or more high intensity sweeteners in an amount of 0.01 to 1% by weight of the chewing gum, and wherein the chewing gum comprises one or more cannabinoids.

Description

technical field [0001] The present invention relates to the field of cannabinoids and the alleviation or treatment of disorders with one or more cannabinoids. In particular, the present invention relates to chewing gum as a vehicle for the mucosal delivery of one or more cannabinoids. Background technique [0002] Generally, only very limited attention has been paid in the prior art to the influence of chewing gum bases and components in such gum bases on cannabinoid release characteristics. Furthermore, less attention has been paid to the influence of gum bases and components in such gum bases on the sensory properties of chewing gums with cannabinoids. Here, important sensory properties include initial chew, texture, flavor perception, sweetness perception, and cannabinoid-related abnormalities. These properties are all relevant from a gum convenience point of view, but of course also to support proper delivery of cannabinoids from the gum and to avoid unwanted side effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23G4/06A61K9/00A23G4/12A23L33/105
CPCA23G4/06A23G4/068A23L33/105A23G4/12A61K9/0058A61K31/05
Inventor 海迪·齐格勒·布鲁恩多特·沙克尔·伯森阿内·埃里克森
Owner 诺狄更斯公司
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