Medical adhesive material for vascular closure and preparation method thereof

A technology of vascular closure and modification, which is applied in the field of medical adhesive materials for vascular closure, can solve the problems of poor hemostasis performance and achieve the effects of increasing film-forming performance, good biocompatibility and good adsorption performance

Active Publication Date: 2021-09-17
卫纳塞德(北京)医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the technical problem to be solved by the present invention is to provide a medical glue material for vascular closure, to solve the problem of s

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation method of the medical adhesive material for vascular closure described in this embodiment comprises the following steps:

[0025] (1) take a certain amount of chitosan and be dissolved in 1% HAc solution and mix well, and constantly add the acetone solution containing succinic anhydride in the stirring process, control the consumption of succinic anhydride to account for the quality of chitosan 30wt% of 30 wt%, at 40°C for heat preservation modification reaction for 8 hours; after the reaction is completed, filter and collect the solid phase and add ethanol to soak for a period of time, filter and collect the precipitate, dissolve it in distilled water, add 3 times the volume of acetone to precipitate, and collect the precipitate Then wash with ethanol and acetone successively, and dry to obtain the required N-succinylated chitosan, which is set aside;

[0026] (2) According to the mass ratio of 1:0.8:2, the above-mentioned N-succinylated chitosan, gluco...

Embodiment 2

[0029] The preparation method of the medical adhesive material for vascular closure described in this embodiment comprises the following steps:

[0030] (1) take a certain amount of chitosan and be dissolved in 1% HAc solution and mix well, and constantly add the acetone solution containing succinic anhydride in the stirring process, control the consumption of succinic anhydride to account for the quality of chitosan 30wt% of 30 wt%, at 40°C for heat preservation modification reaction for 8 hours; after the reaction is completed, filter and collect the solid phase and add ethanol to soak for a period of time, filter and collect the precipitate, dissolve it in distilled water, add 3 times the volume of acetone to precipitate, and collect the precipitate Then wash with ethanol and acetone successively, and dry to obtain the required N-succinylated chitosan, which is set aside;

[0031] (2) According to the mass ratio of 1:0.5:1, the above-mentioned N-succinylated chitosan, gluco...

Embodiment 3

[0034] The preparation method of the medical adhesive material for vascular closure described in this embodiment comprises the following steps:

[0035] (1) take a certain amount of chitosan and be dissolved in 1% HAc solution and mix evenly, and constantly add the acetone solution containing succinic anhydride in the stirring process, control the consumption of succinic anhydride to account for the mass of chitosan 30wt% of 30 wt%, at 40°C for heat preservation modification reaction for 8 hours; after the reaction is completed, filter and collect the solid phase and add ethanol to soak for a period of time, filter and collect the precipitate, dissolve it in distilled water, add 3 times the volume of acetone to precipitate, and collect the precipitate Then wash with ethanol and acetone successively, and dry to obtain the required N-succinylated chitosan, which is set aside;

[0036] (2) According to the mass ratio of 1:1:3, the above-mentioned N-succinylated chitosan, glucoman...

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PUM

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Abstract

The invention belongs to the technical field of biomedical materials, particularly relates to a medical adhesive material for vascular closure, and further discloses a preparation method of the medical adhesive material. The medical adhesive material for vascular closure is prepared from succinylated modified chitosan, glucomannan and oxidized cellulose as matrix fibers, a cyanoacrylate-loaded medical adhesive material, a thickening agent and an activating agent, has better adsorbent film-forming property, also has a blood vessel closure effect and and facilitates hemostasis and bonding healing of an affected part. The medical adhesive material for vascular closure has good biocompatibility, and is free of toxicity and stimulation and suitable for clinical hemostasis and wound healing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a medical glue material for vascular closure, and further discloses a preparation method thereof. Background technique [0002] Medical glue refers to the preparation, material or substance that can adhere to the surface or make the surface bond in the medical application. It belongs to the special functional adhesive of biomedicine. It is mainly used for local adhesion and repair of organs or tissues. Traditional suturing, or the combination and positioning of tissues and blood vessels for closure and other technical fields, in addition to the usual bonding and mechanical functions, also has biomedical functions. Compared with traditional methods such as suturing and stapling, the use of medical glue can effectively shorten the operation time and significantly reduce the pain of patients. It is the preferred material for medical operations at present. [0003] At p...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/08A61L24/001A61L2400/04C08L5/08C08L1/04C08L5/00Y02W90/10
Inventor 王威田霞张俊杰张怡婷李俊超李晓芳王占光梁永菡
Owner 卫纳塞德(北京)医疗科技有限公司
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