A kind of highly active pt complex and its preparation method and application
A complex and high-activity technology, which is applied in the fields of pharmaceutical formulations, organic active ingredients, platinum-based organic compounds, etc., can solve the problems of restricting clinical use and discounting of therapeutic efficacy, and achieves overcoming cisplatin resistance. The preparation method is simple and easy The effect of good performance and great application prospects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0024] Preparation of compound a2:
[0025] Add 3.00 g of cisplatin (10.00 mmol) into 180 mL of hydrogen peroxide (30%-35%) solution, avoid light, heat up to 75°C for 7 h, cool down to room temperature, refrigerate overnight, filter, The filter cake was washed with a small amount of cold water, the solid was collected, and evaporated to dryness under reduced pressure to obtain 2.90 g of compound a2 as a yellow solid with a yield of 87%.
Embodiment 1
[0027] A kind of highly active Pt (IV) complex, its preparation method comprises the steps:
[0028]
[0029] Add 0.42 g compound a2 (1.26 mmol) and 0.80 g compound b (3.80 mmol) to 10 ml DMF solution, then add 1.22 g TBTU (3.80 mmol) and 0.38 g (3.80 mmol) triethylamine, and react at 25°C for 72 h, after the reaction, the solvent was evaporated under reduced pressure, 20 mL of methanol was added, solids were precipitated, filtered, and the filter cake was rinsed with methanol, evaporated to dryness under reduced pressure to obtain a brown solid, complex 1; 1 H NMR, 13 C NMR and MS characterize the brown solid product obtained, and the obtained data are as follows:
[0030] 1 H-NMR (400 MHz, DMSO-d6): δ (ppm) 7.85 (d, J = 1.7 Hz, 2H), 7.78 (d, J = 8.4 Hz, 2H), 7.39 (dd, J = 8.3, 1.8 Hz , 2H), 6.79 (br, 6H), 2.48 (s, 6H).
[0031] 13 C-NMR (400 MHz, DMSO-d6): δ (ppm) 166.86, 153.61, 142.53, 132.10, 128.38, 124.13, 122.98, 122.73, 112.48, 10.00
[0032] ESI-MS(negative ...
Embodiment 2
[0034] A kind of highly active Pt (IV) complex, its preparation method comprises the steps:
[0035]
[0036] Add 0.10 g compound a2 (0.30 mmol) and 0.19 g compound c (0.90 mmol) to 10 ml DMF solution, then add 0.29 g TBTU (0.90 mmol) and 0.09 g (0.90 mmol) triethylamine, and react at 25°C for 72 h, after the reaction, the solvent was evaporated under reduced pressure, 20 mL of methanol was added, solids were precipitated, filtered, and the filter cake was rinsed with methanol, evaporated to dryness under reduced pressure to obtain a brown solid, complex 1; 1 H NMR, 13 C NMR and MS characterize the brown solid product obtained, and the obtained data are as follows:
[0037] 1 H-NMR (400 MHz, DMSO-d6): δ (ppm) δ (ppm) 7.63 (s, 2H), 7.49 (d, J =8.7 Hz, 2H), 7.43 (d, J = 8.9 Hz, 2H) , 6.79 (br, 6H), 2.60 (s, 6H).
[0038] 13 C-NMR (400 MHz, DMSO-d6): δ (ppm) 161.56, 153.72, 141.35, 133.20, 128.72, 127.37, 124.60, 120.58, 112.93, 9.53
[0039] ESI-MS (positive mode, m / z) ...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More - R&D
- Intellectual Property
- Life Sciences
- Materials
- Tech Scout
- Unparalleled Data Quality
- Higher Quality Content
- 60% Fewer Hallucinations
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com