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Method for diagnosing human t-cell leukemia virus type 1 (htlv-1) associated diseases

A diagnostic method and disease technology, applied in the field of diagnosis of human T-cell leukemia virus type 1 (HTLV-1) related diseases, can solve problems such as unsatisfactory

Pending Publication Date: 2021-10-01
NEC CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the latest report, the median survival period of "aggressive ATL" is only 13 months, which is not satisfactory

Method used

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  • Method for diagnosing human t-cell leukemia virus type 1 (htlv-1) associated diseases
  • Method for diagnosing human t-cell leukemia virus type 1 (htlv-1) associated diseases
  • Method for diagnosing human t-cell leukemia virus type 1 (htlv-1) associated diseases

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preparation example Construction

[0345] The preparation methods of these detection reagents are well known in the art. In addition, appropriate detection reagents are also commercially available.

[0346] The detection reagent is preferably labeled for detection by optical, magnetic or electrical means.

[0347]The detection reagent is preferably labeled with a fluorescent substance having an excitation wavelength and an emission wavelength suitable for detection with a commercially available fluorescence analyzer. As fluorescent substances, phycoerythrin (PE), fluorescein isothiocyanate (FITC), rhodamine (RH), TEXAS RED (TX), Cy3, Hoechst33258, and 4', 6-diamidino- 2-phenylindole (DAPI) and the like.

[0348] In the case of using a fluorescently labeled detection reagent, the detection reagent is first bound to a solid phase. Next, the solid phase is brought into contact with the blood sample to allow it to react, and then, if necessary, it is washed. For fluorescent labeling of a labeled protein held on...

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Abstract

Provided as a technology for enabling simple and accurate diagnosis of human T-cell leukemia virus type 1 (HTLV-1) associated diseases is a method for diagnosing HTLV-1 associated diseases, the method comprising: a step for measuring, in a blood sample collected from a subject, the amount of a marker protein which is one or more selected from proteins shown in tables 1 and 2; and a step for, when the value of said measurement is not less than or not more than a predetermined reference value, determining that the subject is affected by a HTLV-1 associated disease or that remission of a HTLV-1 associated disease has occurred in the subject.

Description

technical field [0001] The invention relates to a method for diagnosing diseases related to human T-cell leukemia virus type 1 (HTLV-1). Specifically, it relates to a diagnostic method and a diagnostic kit for an HTLV-1-related disease using a marker protein in blood. Background technique [0002] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that mainly infects CD4-positive T cells and causes adult T-cell leukemia (ATL). In addition, HTLV-1 is also the cause of HTLV-1-associated myelopathy (HAM) and HTLV-1 uveitis (HTLV-1uveitis: HU). Hereinafter, ATL, HAM and HU are collectively referred to as "HTLV-1-associated diseases". [0003] ATL is a malignant blood tumor that infiltrates various internal organs throughout the body, and is classified into four types: acute type, lymphoma type, chronic type, and smoldering type. The acute type and the lymphoma type are also called "aggressive (aggressive) ATL", which are the hematopoietic malignancies with the worst ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/435G01N33/68
CPCG01N33/56988
Inventor 吉原庆子福岛卓也宫良惠美
Owner NEC CORP
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