Application of recombinant humanized collagen and related composition and preparation method thereof

A collagen and humanized technology, applied in the field of biomedicine, can solve the problems of low efficacy, drug resistance of children's skin, and adverse effects of children, and achieve the effects of accelerating relief, promoting restoration of luster, and reducing inflammatory reactions

Pending Publication Date: 2021-10-08
SHANXI JINBO BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used products such as Fule Cream and Lefu Cream contain a small amount of hormones more or less, and long-term use will cause adverse effects on children.
And according to clinical reports, after long-term use of products such as Fule Cream and Lefu Cream, children's skin will develop drug resistance, making the effect less and less effective

Method used

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  • Application of recombinant humanized collagen and related composition and preparation method thereof
  • Application of recombinant humanized collagen and related composition and preparation method thereof
  • Application of recombinant humanized collagen and related composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Recombinant humanized collagen treats eczema

[0041] 1. Recombinant humanized collagen relieves skin symptoms caused by eczema

[0042] 1.1 Establishment of experimental animal models (refer to "Specifications for the Preparation of Animal Models of Eczema (Draft)" to set up experimental models)

[0043] The 42 rats were divided into seven groups, namely control group, COL1 low concentration group, COL1 medium concentration group, COL1 high concentration group, COL2 low concentration group, COL2 medium concentration group and COL2 high concentration group, with 6 rats in each group. Divide the skin on the back of the rat into two parts, A and B, where part A is around the neck and part B is the back, and depilate it. The depilatory area of ​​part A is about 2cm×2cm, and the depilatory area of ​​part B is about 4cm×4cm . Prepare a solution of 2,4-dinitrochlorobenzene (DNCB) in acetone with a concentration of 7%, draw 100 μL with a pipette and apply it on...

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Abstract

The invention relates to an application of recombinant humanized collagen and a related composition and a preparation method thereof. Specifically, the invention provides the application of the recombinant humanized collagen in preparation of a product for preventing and / or treating allergic skin diseases (especially eczema), and also provides the composition containing the recombinant humanized collagen and the preparation method thereof. Experiments prove that the recombinant humanized collagen can effectively relieve skin redness and swelling, erythema, edema, pruritus and inflammatory response caused by eczema and can restore the skin gloss, and compared with a pure recombinant humanized collagen aqueous solution, the composition containing the recombinant humanized collagen can more quickly relieve eczema symptoms.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the use of recombinant humanized collagen, a related composition, and a preparation method of the composition. Background technique [0002] Infant eczema is a common disease in children. Children are not easy to take medicine because of their low immunity and weak liver and kidney function. The commonly used products such as Fule Cream and Lefu Cream contain a small amount of hormones more or less, and long-term use will cause adverse effects on children. And according to clinical reports, after long-term use of products such as Fule Cream and Lefu Cream, children's skin will develop drug resistance, making the effect less and less. Therefore, it is necessary to develop more hormone-free products for the treatment of skin eczema, so as to provide more choices for patients. [0003] The patent application with the application number 201811438582.6 and the title of the invention "polype...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P17/00A61P37/08A61K8/65A61Q19/00
CPCA61K38/39A61P17/00A61P37/08A61K8/65A61Q19/00A61K2800/10
Inventor 杨霞何振瑞陈传秀王志强岳海霞高桂芝樊艳勤郝睿杨岩张彦邢彦雪马淼
Owner SHANXI JINBO BIO PHARMA CO LTD
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