Blood coagulation analyzer reagent calibration method based on immunoturbidimetry

A technology of coagulation analyzer and turbidimetry, which is applied in the field of reagent calibration of coagulation analyzer based on immunoturbidimetry, can solve the problems of inapplicability, single method, single parameter or calculation method, etc., and achieves the effect of strong applicability

Pending Publication Date: 2021-10-08
江苏鸿恩医疗器械有限公司
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Problems solved by technology

The same method and experimental conditions may not be applicable to different brands of coagulation analyzers or coagulation reagents
Moreover, the coagulation analyzers and coagulation reagents currently on the market only us...

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  • Blood coagulation analyzer reagent calibration method based on immunoturbidimetry

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Embodiment Construction

[0019] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0020] A preferred embodiment of the present invention discloses a reagent calibration method for a coagulation analyzer based on immunoturbidimetry, the method comprising:

[0021] According to the fact that the absorbance difference is proportional to the concentration of the calibration sample, the calibration samples with different concentrations were used for multiple experiments to calculate the absorbance difference of the plasma samples with different concentrations. For the calibration samples with different concentrations, the two-point method and the rate method were used Calculate the difference in absorbance, and obtain two calibration curves respectively; wherein, the conc...

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Abstract

The invention discloses a blood coagulation analyzer reagent calibration method based on immunoturbidimetry, and the method comprises the following steps: carrying out multiple experiments by using calibration samples with different concentrations of measured components according to the direct proportion of absorbance difference to the concentration of the calibration samples, calculating the absorbance difference of plasma samples with different concentrations of measured components, respectively adopting a two-point method and a rate method to calculate absorbance difference values for calibration samples with different concentrations of measured components, and respectively obtaining two calibration curves. According to the reagent calibration method for the blood coagulation analyzer based on the immunoturbidimetry, two different calibration curves are used on the basis of combining actual clinical application conditions and experimental experience accumulation aiming at detected component samples with different concentrations, and two calibration methods are adopted, so that the calibration method is more flexible, accurate and high in applicability.

Description

technical field [0001] The invention relates to the technical field of coagulation detection, in particular to a reagent calibration method of a coagulation analyzer based on immunoturbidimetry. Background technique [0002] Immunoturbidimetry is a commonly used coagulation detection method, which is specially used to detect the reaction of liquid turbidity change caused by latex agglutination. [0003] The test principle is: the sample and mouse anti-human monoclonal antibody latex particles react in the test cup to form antigen-antibody complex particles, resulting in turbidity changes. The light source and receiver are arranged at 90 degrees on both sides of the test cup, which can detect the absorbance change of the liquid in the test cup. The absorbance has a correlation with the liquid turbidity, and the change of the optical signal is received and converted into an electrical signal, which is then amplified and calculated. [0004] For the coagulation analyzers and ...

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Application Information

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IPC IPC(8): G01N21/17G01N33/53G01N33/543
CPCG01N21/17G01N33/54366G01N33/5302
Inventor 丁鸿
Owner 江苏鸿恩医疗器械有限公司
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