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Calculus dissolving agent for interventional dissolution of gall-stone

A technology for gallstones and stone-dissolving, applied in the field of new stone-dissolving agents, can solve problems such as high toxicity, irritation, and intestinal irritation, and achieve the effect of accelerating stone-dissolving, reducing human burden, and reducing side effects.

Pending Publication Date: 2021-10-22
宁海德宝立新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methyl tert-butyl ether has shown many side effects in clinical practice. It can stimulate human tissues, cause biliary muscle spasm, stimulate the intestinal tract, enter the liver and cause hepatic lobular necrosis, and some residues in the body will cause hemolysis and kidney failure. Therefore, , has not been widely used, and many new stone-dissolving agents have been tried to replace methyl tert-butyl ether
The existing stone-dissolving agents have poor stone-dissolving effect with low toxicity, especially for mixed gallstones and pigmented gallstones, which are almost insoluble. The stone-dissolving effect is good, and the toxicity is high, which is likely to cause a large number of side effects and damage the human body.

Method used

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  • Calculus dissolving agent for interventional dissolution of gall-stone
  • Calculus dissolving agent for interventional dissolution of gall-stone
  • Calculus dissolving agent for interventional dissolution of gall-stone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Embodiment 1

[0056] Weigh three light yellow cholesterol-type gallstones of about 0.1g (the gallstones come from a patient, female, 44 years old) and place them in stone-dissolving agent 1-1, stone-dissolving agent 1-2, and stone-dissolving agent 1-3 respectively, Use an ultrasonic cleaner (ultrasonic power 240W) to break and dissolve.

[0057] Stone dissolving agent 1-1: dipropylene glycol butyl ether: water: poloxamer=3mL: 30mL: 1.2g.

[0058] Stone dissolving agent 1-2: dipropylene glycol butyl ether: water: poloxamer=3mL: 10mL: 0.4g.

[0059] Stone dissolving agent 1-3: dipropylene glycol ether: water: poloxamer=5mL: 10mL: 0.4g.

[0060] At 30 minutes, the gallstones in the dissolving agent 1-2 were completely dissolved, such as image 3 Shown; 40min, the gallstones in dissolving stone agent 1-1 dissolve completely, as figure 2 Shown; When 50min, the gallstone in dissolving stone agent 1-3 dissolves completely, as Figure 4 shown. The above stone-dissolving agents all change from...

Embodiment 2

[0062] Weigh two about 0.1g black pigment gallstones (the gallstones come from a patient, man, 67 years old, gallbladder stones) and place them in the stone-dissolving agent 1-1 and the stone-dissolving agent 1-2 respectively. Use an ultrasonic cleaner (ultrasonic power 240W) to crush and dissolve the stones.

[0063] At 190 minutes, the gallstones in the stone-dissolving agent 1-2 were completely dissolved, and at 270 minutes, the gallstones in the stone-dissolving agent 1-1 were completely dissolved, such as Figure 5 shown. The stone-dissolving agent changes from the original colorless transparent solution to milky white, then gradually turns yellow and deepens, and finally turns reddish brown and non-transparent. After standing still, use a syringe with a needle diameter of 0.7 mm and 10 ml to suck out the litholytic agent in the beaker. A small amount of fine powdery substances remain in litholytic agents 1-1 and 1-2.

Embodiment 3

[0065] Weigh two complete brown mixed gallstones of about 0.15g (the gallstones come from a patient, female, 33 years old) and place them in the stone-dissolving agent 1-1 and the stone-dissolving agent 1-2 respectively. Use an ultrasonic cleaner (ultrasonic power 240W) to crush and dissolve the stones.

[0066] At 50 minutes, brown mixed gallstones in litholytic agent 1-1 were completely dissolved; at 70 minutes, brown mixed gallstones in litholytic agent 1-2 were completely dissolved. In the process of dissolving stone, the original colorless and transparent solution of the above-mentioned dissolving stone agent first becomes milky white, and then gradually becomes milky yellow, such as Figure 6 shown. The stone-dissolving agent has stratification phenomenon in the process of dissolving mixed gallstones. Among them, the stratification phenomenon of stone-dissolving agent 1-2 is more obvious, and the stone-dissolving agent 1-1 has only a small amount of stratification in th...

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Abstract

The invention provides a gall-stone dissolving agent, polypropylene glycol ether and water are mixed to prepare the gall-stone dissolving agent, and the gall-stone dissolving agent is directly introduced into a gall bladder and is in direct contact with the gall-stone for dissolving. The gall-stone dissolving agent can dissolve cholesterol type, biliary pigment type and mixed type gall-stone, the usage amount of the ether solvent is reduced, and the side effects of a human body are reduced, so that the gall-stone dissolving agent is expected to be used for clinical non-surgical treatment of gall-stone patients.

Description

technical field [0001] The invention relates to a novel stone-dissolving agent for dissolving gallstones, in particular to a polypropylene glycol ether type stone-dissolving agent. Background technique [0002] Worldwide, the incidence of gallstones is very high, reaching 1% to 10% of the general population. In my country, the incidence of gallstones is at least 7% of the natural population, and there is an increasing trend year by year. Gallstones are a disease of stones that develop in the bile ducts or in the gallbladder. After the formation of gallstones, it can cause cholecystitis, cholangitis and pancreatitis, etc. The treatment of gallstones has always attracted people's attention. [0003] The treatment methods for gallstones are mainly divided into surgical treatment or non-surgical treatment. Although surgical treatment is effective, there are certain indications for surgery, and minimally invasive surgery can also induce gallstones. Therefore, conservative treat...

Claims

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Application Information

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IPC IPC(8): A61K31/08A61K47/10A61P1/16
CPCA61K31/08A61K47/10A61P1/16
Inventor 倪磊宋红红陈梓衡张杰凌晓峰徐怡庄冯娟
Owner 宁海德宝立新材料有限公司