Intelligent rat and mouse forced swimming device

Abstract

The invention discloses an intelligent rat and mouse forced swimming device, and relates to the technical field of animal behavioral experimental equipment. The intelligent rat and mouse forced swimming device comprises a computer, a controller and a plurality of forced swimming units, the computer is configured to control the operation of the controller, the controller is configured to control the plurality of forced swimming units, and any forced swimming unit comprises a transparent swimming container, a shell, a constant-temperature adjusting mechanism, a liftable filter screen, a clean water supply mechanism, a transparent observation window, an electronic display panel, a drying mechanism, a drainage pipe, a sewage purifier, a discharge pipe and a movable digital camera. According to the intelligent rat and mouse forced swimming device, intelligent experiment operation of forced swimming of rats and mice is achieved, experiments can be conducted on multiple channels at the same time, the experiment efficiency is improved, and the experiment quality is ensured.

Description

technical field [0001] The invention relates to the technical field of animal behavior experiment equipment, in particular to an intelligent forced swimming device for rats and mice. Background technique [0002] The Forced Swimming Test (FST) provides an unavoidable oppressive environment by placing experimental animals in a confined environment (such as water), where the animal struggles desperately trying to escape but cannot escape, After a period of experimentation, the animals showed a typical "suspension and immobility state", reflecting a state called "behavioral despair", and recorded a series of events in the process of animals in this environment producing behavioral despair. parameter. The forced swimming test system is suitable for rats, mice or other laboratory animals. As a widely used animal behavior paradigm, it is often used to establish animal models of depression or evaluate the depression state of animals. It is used in the study of neuropsychiatric dis...

AI Technical Summary

Problems solved by technology

Many laboratories use black or white wallpaper to stick behind the glass tank. This method is not only cumbersome to operate, but the wallpaper needs to be replaced repeatedly according to the fur color of the animal. It is not easy to clean the glass tank, and it will be affected by room lighting and personnel movement, resulting in reflective effects. Data Acquisition and Analysis

[0004] 2. The traditional video collection is to fix the camera on a tripod and place it in front of the glass barrel. This method requires multiple adjustments before each experiment so that the animals in the glass barrel are located in the center of the camera collection range, and when people move It is easy to touch the camera, and it needs to be re-adjusted, which is time-consuming and laborious

[0005] 3. Most of the instruments are now single-channel, and can only test one animal at the same time; however, multi-channel equipment has problems such as cumbersome operation, inaccurate tracking, and inability to start / pause at the same time, which reduces the efficiency of the experiment

[0006] 4. In view of the particularity of animal experiments, various irrelevant variables need to be strictly controlled, otherwise it will easily lead to inaccurate experimental data

The existing experimental equipment is manually filled with water, and the water temperature and water level are difficult to be consistent, and it is easy to produce differences caused by irrelevant variables between the animal groups before and after the test, which will affect the experimental results; The impact of animal behavior is greater. However, the experimental test takes a long time, and the water temperature will inevitably drop. It is difficult to keep the water temperature of each channel in the same batch of tests consistent. The impact of this error on the experimental results is difficult to estimate, and it may even cause The experiment ran counter to the original purpose, and all previous efforts were wasted

[0007] 5. In the past, after the experiment, the equipment needed to manually salvage the animals, and when the animals sensed the approach of a strange object in the water, they would instinctively produce a stress response to attack, and it was very easy to bite and scratch the experimenter; and during the experiment In the process, if the animal is exhausted and cannot be salvaged in time, it will cause the animal to drown and die, which will affect the continuation of the experiment.

[0008] 6. If the experimental animals are not kept warm and cleaned and dried in time after they are taken out, it is easy to catch a cold and lead to death; after wiping with a towel, the residual moisture on the animal will cause the litter to be wet, and it will easily cause the animal to get sick and affect the same environment. group animals and does not meet animal welfare requirements

[0009] 7. After the experiment is over, it is necessary to manually salvage the feces in the barrel, dump the waste water, and clean the barrel wall with water many times, which is time-consuming and laborious, and the waste water is easily splashed during the process, which will not only pollute the laboratory environment, but also easily cause people to slip or equipment failure and other safety hazards

Images