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Application of brazilin to synergism of antibacterial effect of polymyxin antibiotics on escherichia coli

A technology of Brazilian hematoxylin and polymyxin, which is applied in the fields of medicine and animal bacterial disease prevention and control, and can solve the problems of the decline of the treatment effect of Gram-negative bacteria

Pending Publication Date: 2021-11-02
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the increasing use of colistin in clinical, animal husbandry and agriculture and the occurrence of other antibiotic abuses, its therapeutic effect on Gram-negative bacteria has relatively declined, and a variety of colistin resistance has emerged. Gram-negative bacteria

Method used

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  • Application of brazilin to synergism of antibacterial effect of polymyxin antibiotics on escherichia coli
  • Application of brazilin to synergism of antibacterial effect of polymyxin antibiotics on escherichia coli
  • Application of brazilin to synergism of antibacterial effect of polymyxin antibiotics on escherichia coli

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Colistin dosage form prescription and packaging:

[0087] Pack polymyxin 0.1g in powder form

[0088] Brazilian hematoxylin drug:

[0089] Pack Brazilian hematoxylin 3.2-6.4g in powder form

[0090] Combined packaging:

[0091] The polymyxin and brazilian hematoxylin are packaged into their respective medicines, and then the two medicines are packed together into the same large packaging box, and the two boxes of powder are mixed and taken when used.

Embodiment 2

[0093] Colistin drugs and packaging:

[0094] The polymyxin tablet is made into 0.5g per tablet, and the effective dose of each polymyxin tablet is 0.45g

[0095] Brazilian hematoxylin drug and packaging

[0096] Brazilian hematoxylin was packaged in powder form with 14.4 g of brazilian hematoxylin at a weight ratio of 1:32. Combined packaging:

[0097] The polymyxin tablet and brazilian hematoxylin powder are packaged into respective medicines respectively, and then the two kinds of medicines are packed together into a large packing box, and the colistin tablet is taken orally, and the brazilian hematoxylin is taken after mixing.

Embodiment 3

[0099] Colistin drugs and packaging:

[0100] The polymyxin tablet is made into 0.5g per tablet, and the effective dose of each polymyxin tablet is 0.45g

[0101] Brazilian hematoxylin drug and packaging

[0102] Brazilian hematoxylin was packaged in powder form with 28.8 g of brazilian hematoxylin at a weight ratio of 1:64. Combined packaging:

[0103] The polymyxin tablet and brazilian hematoxylin powder are packaged into respective medicines respectively, and then the two kinds of medicines are packed together into a large packing box, and the colistin tablet is taken orally, and the brazilian hematoxylin is taken after mixing.

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Abstract

The invention relates to application of brazilin in enhancing the antibacterial effect of polymyxin antibiotics on chicken-origin escherichia coli, and finds that brazilin can enhance the antibacterial effect of the polymyxin antibiotics on the escherichia coli for the first time, so the minimum inhibitory concentration is obviously reduced. A new strategy of drug combination is provided, and the brazilin serving as a natural traditional Chinese medicine compound has important drug research and development and clinical application values.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the combined application of brazilian hematoxylin in synergistic colistin antibiotics against Escherichia coli of chicken origin, and belongs to the field of prevention and treatment of animal bacterial diseases. Background technique [0002] Chicken colibacillosis is an acute or chronic bacterial infectious disease of chickens caused by pathogenic Escherichia coli. [0003] The harm of E. coli in chickens has gradually expanded in recent years. In many chicken farms, the number of dead chickens caused by E. coli often accounts for more than 50% of the deaths. If we want to improve the survival rate and egg production rate of chicken flocks and improve the breeding level, we must work hard to control chicken colibacillosis. Including Escherichia coli peritonitis, salpingitis, omphalitis, synovitis, air sacitis, granuloma, ophthalmia and other diseases, which are more harmful to...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K31/352A61P31/04
CPCA61K38/12A61K31/352A61P31/04A61K2300/00
Inventor 郝智慧任海燕胡龙飞刘旭东王苹苹王帅玉
Owner CHINA AGRI UNIV
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