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Detection of biomarkers in sweat

A biomarker and marker technology, applied in the field of physiologically related biomarkers, can solve problems such as increasing sweat rate and achieve the effect of effective collection

Pending Publication Date: 2021-11-12
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clearly, sweat rate can be increased by exercising, by increasing ambient temperature, or by stimulating the skin; however, this is impractical if it is desired to measure biomarker concentrations in a patient or patient recovering in a general ward, or if one is expected to monitor a person performing a daily routine. actual

Method used

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  • Detection of biomarkers in sweat
  • Detection of biomarkers in sweat
  • Detection of biomarkers in sweat

Examples

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Embodiment Construction

[0055] As described above, provided herein is an improved device, system, and method for quantitatively detecting biomarkers in a sweat sample obtained from the skin of a subject. The device can be configured to be worn by a subject. Therefore, the device can be a wearable device.

[0056] In some embodiments, the device may include a strap (or strap) for placement around a body part of the subject such that the device may be worn in a location suitable for receiving a sample of sweat from the subject. In some embodiments, an adhesive layer for securing the device to the skin of a subject is provided on the underside of the device.

[0057] The device may be configured to be worn by the subject at any location on the subject's body suitable for collecting a sweat sample. In some embodiments, the location may be a location that includes bone near the surface of the skin (eg, to ensure well-defined contact with the skin). For example, in some embodiments, the device may be co...

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Abstract

There is provided a wearable device for quantitatively detecting a biomarker in a sweat sample obtained from the skin of a subject. The wearable device comprises a microfluidic network. The microfluidic network comprises a reservoir filled with a carrier fluid containing a predetermined amount of a marker; a sample collection chamber disposed downstream from the reservoir and adapted to contact the skin of the subject and collect a sweat sample; a first sensor disposed downstream from the sample collection chamber and adapted to detect the marker; and a second sensor disposed downstream from the first sensor and adapted to detect the biomarker.

Description

technical field [0001] The present disclosure relates to devices, methods and systems for detecting physiologically relevant biomarkers in sweat samples obtained from subjects. Background technique [0002] Noninvasive, continuous, and prolonged monitoring of biomarkers indicative of health and well-being is needed, for example for monitoring dehydration, stress, sleep, child health, and perioperative monitoring. Sweat is an unobtrusively accessible biological fluid that contains a wealth of physiological and metabolic information. Some examples of clinically relevant components of sweat are Na+, Cl- and / or K+ for monitoring dehydration, lactate as an early warning of inflammation (associated with sepsis), glucose for diabetics and newborns and cortisol for monitoring sleep and stress. [0003] WO2007 / 146047A1 discloses a patch, system and method for measuring glucose. [0004] Adults generate approximately 100 joules (100 watts) of heat per second at rest. For a person ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145A61B5/00A61B10/00
CPCA61B5/14517A61B5/4266A61B10/0064B01L3/502715B01L2300/047B01L2300/0663B01L2300/069
Inventor E·G·M·佩尔塞斯M·T·约翰逊T·J·范吉耶赛尔R·M·L·范利斯豪特K·H·J·德利莫雷
Owner KONINKLJIJKE PHILIPS NV
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