Physical platform for simulating occurrence and development process of typical pulmonary arterial hypertension

Abstract

The invention discloses a physical platform for simulating the occurrence and development process of typical pulmonary arterial hypertension. The physical platform comprises a liquid storage pipeline, a constant-pressure back-flow container, a compliance container, a flow sensor, a pressure sensor, a servo motor silica gel ventricle, an artificial heart valve, an artificial blood vessel tree, a damper and a silica gel tube. The liquid storage pipeline is filled with working liquid, a proper amount of simulation liquid is added into a circulation loop, the silica gel ventricle is installed on the liquid storage pipeline, the servo motor extrudes a flexible diaphragm under the control of computer programming to generate hydraulic pressure so as to drive the ventricle to pump blood outwards, and complete blood circulation is formed through the peripheral vascular tree, the compliance container and the constant-pressure back-flow container. Elastic cavity model parameters in a vascular system can be calculated according to the pressure sensor, the flow sensor and motor driving parameters. By adjusting the volume of the damper and the compliance container or modifying the motor driving parameters, the resistance and compliance parameters and the ventricular driving process are changed, so that various hemodynamic indexes are similar to the pulmonary arterial hypertension state.

Description

technical field [0001] The invention relates to the field of biomedical engineering, more specifically, to a physical platform for simulating the occurrence and development of typical pulmonary hypertension. Background technique [0002] Pulmonary hypertension refers to a hemodynamic abnormal state in which the arterial pressure exceeds a certain threshold. It is a chronic disease that can eventually lead to right heart failure, severe functional limitation and even death. The mean pulmonary artery pressure obtained by right heart catheterization is greater than or equal to 25mmHg. Because the blood vessels related to the pulmonary circulatory system are basically hidden deep inside the chest cavity, away from the body surface, it has brought great difficulties to the work of measuring and studying pulmonary hypertension. [0003] For other extracorporeal circulation simulation devices that exist today, there is no blood simulation device system for patients with pulmonary ...

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Problems solved by technology

Because the blood vessels related to the pulmonary circulatory system are basically hidden deep inside the chest cavity, away from the body surface, it has brought great difficulties to the work of measuring and studying pulmonary hypertension.

[0003] For other extracorporeal circulation simulation devices that exist today, there is no blood simulation device system for patients with pulmonary arterial hypertension. Since the causes of pulmonary arterial hypertension are many and complex, it is necessary to target the platform according to several typical causes of pulmonary arterial hypertension. design, there are certain difficulties

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