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Application of physalis pubescens lactone B in preparation of medicine for treating diseases associated with cytokine storm

A cytokine, Physalis Physalis technology, applied in extracellular fluid diseases, blood diseases, antibacterial drugs, etc., can solve the problem that there is no application report of Physalis Physalis B, achieve safe and reliable toxic side effects, non-toxic Side effects, effects of excellent anti-inflammatory activity

Pending Publication Date: 2021-12-03
浙江中医药大学附属第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no report on the application of Physalis lactone B in anti-inflammatory drugs

Method used

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  • Application of physalis pubescens lactone B in preparation of medicine for treating diseases associated with cytokine storm
  • Application of physalis pubescens lactone B in preparation of medicine for treating diseases associated with cytokine storm
  • Application of physalis pubescens lactone B in preparation of medicine for treating diseases associated with cytokine storm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] In the following, combined with the activity test and accompanying drawings, the application of the claimed physalis lactone B in the preparation of medicines for treating diseases associated with cytokine storm will be further described in detail. The following activity tests are used to illustrate the present invention, but not to limit the scope of the present invention.

[0040] Activity test:

[0041] 1. Physalis lactone B inhibits the activation of STAT1 signaling pathway in RAW264.7 cells

[0042] Take RAW264.7 cells and adjust the concentration to 3×10 5 The cell suspension was inoculated on a 6-well cell culture plate at a density of cells / mL, and 1 mL of the cell suspension was added to each well, incubated in an incubator for 24 hours, and the supernatant was carefully sucked off. RAW264.7 cells were treated with different concentrations of physalactone B (0 μM, 2.5 μM, 5 μM, 10 μM, 15 μM) for 4 hours, the total protein was extracted, and the phosphorylatio...

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PUM

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Abstract

The invention discloses application of physalis pubescens lactone B in preparation of a medicine for treating diseases associated with cytokine storm. The structural formula of the physalis pubescens lactone B is shown in the specification. The invention also discloses an anti-inflammatory bowel disease medicine which comprises the physalis pubescens lactone B. The inflammatory bowel disease is acute colon injury. The invention discloses the application of the physalis pubescens lactone B in preparation of the medicine for treating the diseases associated with the cytokine storm for the first time, the application range of the physalis pubescens lactone B is further expanded, the physalis pubescens lactone B belongs to a natural active compound, is safe and reliable, does not have toxic or side effects, and has potential development value in the field of preparing the medicines for treating diseases associated with the cytokine storm.

Description

technical field [0001] The invention belongs to the application field of phyllolide B, and in particular relates to the application of phyllolide B in the preparation of medicines for treating diseases associated with cytokine storms and an anti-inflammatory bowel disease medicine. Background technique [0002] The term "cytokine storm" is used to describe abnormally elevated levels of cytokines and chemokines and the accompanying immunopathological process. For example, the levels of cytokines and chemokines are closely related to the morbidity and mortality of inflammatory bowel disease, graft-versus-host disease, sepsis, respiratory virus infection, and hemorrhagic virus infection. At present, no safe and effective method has been developed to treat the pathological process related to cytokine storm. [0003] Inflammatory bowel disease (IBD) is a group of intestinal inflammatory diseases of unknown etiology characterized by chronic non-specific intestinal inflammation, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K36/81A61P1/00A61P29/00A61P11/00A61P31/12A61P7/04A61P1/04A61P37/06A61P31/04
CPCA61K31/58A61K36/81A61P1/00A61P29/00A61P11/00A61P31/12A61P7/04A61P1/04A61P37/06A61P31/04
Inventor 陈喆吕宾金威洋
Owner 浙江中医药大学附属第一医院