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Marker-based product for predicting curative effect of transarterial chemoembolization and application thereof

A marker and response technology, applied in the field of biomedicine, can solve the problems of high degree of malignancy, low success rate of surgical resection, hidden onset of liver cancer, etc.

Inactive Publication Date: 2021-12-14
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Surgical resection is the main method for early liver cancer, but the onset of liver cancer is hidden and the degree of malignancy is high. Most patients are in the middle and late stages when they see a doctor. The success rate of surgical resection is low, and non-surgical treatment is mostly used

Method used

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  • Marker-based product for predicting curative effect of transarterial chemoembolization and application thereof
  • Marker-based product for predicting curative effect of transarterial chemoembolization and application thereof
  • Marker-based product for predicting curative effect of transarterial chemoembolization and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0060] Example, screening differentially expressed genes and verifying their prediction effects

[0061] Before TACE treatment, tumor biopsy samples were collected from liver cancer patients. After surgery, patients were divided into response group (R, responder) or non-responder group (NR, non-responder) according to whether they responded to TACE treatment, and the responses were compared. The gene expression profiles of patients in the control group and patients in the non-responder group can obtain potential markers that can predict the response to TACE treatment. The data source of this study is: GSE104580, non-responder in this data set: responder=66:81.

[0062] Differential analysis was performed with the R language limma package to obtain differentially expressed genes, and the screening criteria were: adj.P.Val1. Differentially expressed genes are shown in Table 1 and figure 1 shown.

[0063] Table 1. Gene expression

[0064] logFC average expres...

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Abstract

The invention belongs to the field of biomedicine, and particularly relates to a marker-based product for predicting the curative effect of transarterial chemoembolization and application thereof. The invention provides a kit for predicting the reaction of a patient to treatment through arterial chemoembolization, the kit comprises a reagent for detecting the expression quantity of any one or more of HILPDA, LIN28B and SLAIN1, and according to the detection result of the expression quantity, whether the patient can obtain a good curative effect after receiving arterial chemoembolization can be predicted.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a marker-based product for predicting curative effect of transarterial chemoembolization and its application. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the malignant tumors with the highest mortality and morbidity in the world. Surgical resection is the main method for early liver cancer, but the onset of liver cancer is hidden and the degree of malignancy is high. Most patients are in the middle and late stages when they see a doctor. The success rate of surgical resection is low, and non-surgical treatment is mostly used. Moreover, more than 90% of patients with liver cancer in my country have a background of hepatitis B infection, liver cirrhosis, liver insufficiency, multi-center tumor occurrence, early spread and metastasis, and only about 20%-30% of patients can obtain the opportunity for surgical resection. [0003] With the development ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12M1/34C12M1/00G01N33/574
CPCC12Q1/6886G01N33/57484G01N33/57438G01N33/57488C12Q2600/158
Inventor 杨承刚郭静
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD