Application of inosine in preparation of medicines for preventing and treating tuberculosis
A tuberculosis and drug technology, applied to the application field of inosine in the preparation of drugs for preventing and treating tuberculosis, can solve the problems of down-regulation, unreported application, unclear action and mechanism, etc., to promote clearance, inhibit in vivo survival, inhibit Effects of exacerbation of tuberculous granulomas
Pending Publication Date: 2021-12-21
SHANGHAI PULMONARY HOSPITAL
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The invention provides an application of inosine in preparation of medicines for preventing and treating tuberculosis. According to the invention, the inosine is proven to significantly reduce microbial load in the lung of an mycobacterium tuberculosis (Mtb) infected mouse, alleviate pathological changes, inhibit deterioration of tuberculous granuloma, and significantly promote expression of IL-1beta and IL-6 genes so as to promote elimination of Mtb by macrophages, thereby inhibiting in-vivo survival of Mtb. Therefore, inosine is expected to serve as a new effective metabolic molecule for preparing medicines for preventing and treating tuberculosis, and provides a new strategy for treating tuberculosis.
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Classification and recommendation of technical efficacy words
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