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Contaminant-depleted nanoparticle composition and method for producing same

A manufacturing method and technology of microparticles, applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., can solve problems such as product pollution, product performance deterioration, and health hazards, and achieve the effect of reducing pollution

Active Publication Date: 2021-12-21
SHIONOGI & CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, when using a bead mill for wet grinding, product contamination may occur due to wear of the grinding media (beads) and grinding components (stirrers, etc.)
[0004] In particular, in the field of high-purity electronic component raw materials and pharmaceuticals, even a small amount of impurities can cause adverse effects such as poor product performance and health hazards.

Method used

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  • Contaminant-depleted nanoparticle composition and method for producing same
  • Contaminant-depleted nanoparticle composition and method for producing same
  • Contaminant-depleted nanoparticle composition and method for producing same

Examples

Experimental program
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Effect test

Embodiment 1

[0105] Phenytoin (Shizuoka Coffee Co., Ltd., SHIZUOKA COFFEIN CO., LTD.) 7.5g (5w / w%) was used as a drug, polyvinylpyrrolidone (PVP K-25, BASF Japan) 4.5g (3w / w%) was used as a Molecule, sodium lauryl sulfate (Cognis Japan, COGNIS JAPAN LTD.) 0.375 g (0.25 w / w %) was dispersed as a surfactant in 137.6 g of purified water to prepare a slurry. The pH of the slurry was 3.88. A 1N sodium hydroxide aqueous solution was added to this slurry to adjust the pH, and samples of various pH (pH6.07, 6.68, 7.36, 8.14, 8.96, 10.37) were prepared.

[0106] Each sample (100g) and beads (217.3g, filling rate 70%) were loaded into a DYNO-MILL RESEARCH LAB bead mill (manufactured by WAB Company), and pulverized by the bead mill for 120 minutes (disc speed: 4m / s, product temperature: 20°C, liquid velocity: 45g / min). The beads used for the pulverization treatment were YTZ balls (particle size: 0.5 mm, zirconia beads manufactured by NIKKATO Co., Ltd.). Here, the filling rate refers to the ratio ...

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Abstract

A production method according to the present disclosure comprises a) a step of stirring, with a bead mill, a mixture comprising a material to be milled, beads, and a dispersion medium; and b) a step of adjusting the pH of the mixture. This method reduces the contamination caused by milling processes with a bead mill.

Description

technical field [0001] The present disclosure relates to a method of miniaturizing solid particles using a bead mill and particles miniaturized by the method. Background technique [0002] Wet pulverization using a pulverizing device such as a bead mill is known as a means for miniaturizing solid particles. The wet pulverization by the bead mill has a high pulverization ability for the particles, and the particles can be miniaturized to a submicron particle size. [0003] The bead mill is a device that agitates the pulverization medium (beads) with a stirrer in a pulverization chamber (chamber) to impart a large amount of kinetic energy to the beads, thereby making the particles finer by the collision force and shear force of the beads. Therefore, when using a bead mill for wet grinding, product contamination may occur due to wear of the grinding media (beads) and grinding components (stirrer, etc.). [0004] Especially in the field of high-purity electronic component raw ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B02C17/00B02C17/16B02C17/20A61K9/14
CPCB02C17/16B02C17/00B02C17/20A61K9/145A61K9/146A61K9/14B82Y5/00B82Y40/00
Inventor 田中宏典落井裕也茨城哲治
Owner SHIONOGI & CO LTD