Shell material, nano-carrier and application thereof

Abstract

The invention belongs to the field of cosmetics, and discloses a shell material. The shell material comprises phospholipid, a peptide fatty acid derivative and triol type ginsenoside secondary glycoside, wherein the weight ratio of the phospholipid to the peptide fatty acid derivative to the triol type ginsenoside secondary glycoside is (0.1-100): (0.1-100): (0.1-100); the peptide fatty acid derivative comprises a polypeptide unit structure and contains one or more arginine or lysine units; and the polypeptide unit structure is one of dipeptide to pentapeptide. The shell material can be used as a shell layer of micelle and lipidosome to stably wrap and stably release lipophilic active substances and hydrophilic active substances, and shows excellent compatibility in a system; the precipitation phenomenon is obviously weakened; the positive and negative performance of charges on the surface of the shell material is easy to regulate and control; the cytotoxicity and skin irritation of the cosmetics are reduced; the adverse proliferation effect of the traditional shell material on harmful flora as nutrient substances is reduced; and the absorption effect of the skin on the active substances is improved. Meanwhile, the invention further discloses application of the micelle and the lipidosome.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a shell material, a nano-carrier and uses thereof. Background technique [0002] CN2020116376570 discloses a liposome based on ginsenoside secondary glycosides, which contains phospholipids and diol type ginsenoside secondary glycosides as shown in formula (1); discloses a liposome loaded with active substances Liposome, the liposome loaded with active substances refers to the encapsulation of one or more active substances in cosmetics in liposomes based on diol-type ginsenoside secondary glycosides; the invention loads active substances The preparation method of the liposome of the substance, mixes the phospholipid and the ginsenoside secondary glycoside shown in formula (1) in an alcoholic organic solvent, then adds the active substance in the cosmetics, and evaporates under reduced pressure until the film is formed , and then use a phosphate buffer solution with a pH value of 7-8 as ...

AI Technical Summary

Problems solved by technology

[0008] The problems in the above research are: CN2020116376570 discloses the structure of liposomes used to accommodate water-soluble active substances, and the obtained liposomes are all liposome structures based on diol-type ginsenosides, CN201310155639. 2. The disclosed shell structures are all pure ginsenosides and do not contain other chemical components. The prepared pure ginsenoside nanomicelles are all neutral or weakly negatively charged nanomaterials. After research, their high-temperature long-term storage stability has certain challenges , unable to meet the needs of encapsulation, storage and release of stable oil-soluble active substances in cosmetics

[0010] Regarding ginsenoside secondary glycosides as the shell material, we have found through research that if the shell material is not optimized, its solubility compatibility in the system, skin adsorption, irritation, soothing and anti-allergic effects, reducing the membrane material itself as The effect of nutrients on the proliferation of bacteria is not up to the ideal level

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