Composition for preventing and treating coronavirus infection

Abstract

The invention provides a composition for preventing and / or treating coronavirus infection, which comprises beta-caryophyllene, a derivative of the beta-caryophyllene and / or pharmaceutically acceptable salt of the beta-caryophyllene; preferably, the coronavirus is SARS-CoV or SARS-CoV-2. According to the invention, the beta-caryophyllene can effectively inhibit SARS-CoV-2 from entering ACE2 high-expression cells, so that replication of novel coronavirus can be effectively inhibited, and therefore, the composition provided by the invention can effectively prevent and / or treat diseases caused by coronavirus infection, and can be applied as an anti-pneumonia drug.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and lung disease, and relates to a composition for preventing and / or treating coronavirus infection. Background technique [0002] Coronaviruses belong to the order Coronaviridae, the family Coronaviridae, and the genus Coronaviridae. For different clinical conditions ranging from the common cold to severe lung infections such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). [0003] Novel coronavirus 2019-nCoV (named by WHO) is a new type of coronavirus that has not been found in humans before. In February 2020, the International Committee on Taxonomy of Viruses determined the official classification name of the new coronavirus (2019-nCoV) as severe acute respiratory syndrome coronavirus 2, the English abbreviation SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). SARS-CoV-2 and SARS-CoV belong to the coronavirus β family and have similar pat...

AI Technical Summary

Problems solved by technology

[0004] At present, Western medicine treatment mainly focuses on strengthening supportive treatment, ensuring sufficient heat, paying attention to water and electrolyte balance, and giving oxygen therapy, antiviral treatment and antibacterial treatment when necessary. Chloroquine drugs, there may be greater side effects

[0005] Traditional Chinese medicine treatment has obvious advantages in preventing the onset of the disease, improving clinical symptoms, preventing mild to severe, and severe to critical. For the treatment of this new type of coronavirus pneumonia, "three prescriptions and three medicines" have better therapeutic effects. However, it contains prohibited medicinal materials such as ephedra gypsum, which also limits the overseas application of traditional Chinese medicine.

[0006] β-Caryophyllene is a bicyclic sesquiterpenoid compound, which exists in many plant volatile oils, such as clove volatile oil, dried ginger volatile oil, pepper volatile oil or cinnamon volatile oil, etc. Because of its low toxicity, the US FDA defines it as GRAS (generally recognized as safe) food compounds, and approved for use in cosmetics and food additives; there is not much information about the medical application of β-caryophyllene

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