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Application of bakuchiol in preparation of medicine for treating acute myocardial infarction

A technology of bakuchiol and myocardial infarction, which is applied in the field of medicine, can solve the problems such as unclear influence of cardiac function and myocardial fibrosis, improve cardiac ejection fraction and contractility, improve cardiac dysfunction, and improve the reversal of myocardial fibrosis Effects of left ventricular remodeling

Pending Publication Date: 2021-12-31
上海市静安区中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect of bakuchiol on cardiac function and myocardial fibrosis after myocardial infarction is unclear

Method used

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  • Application of bakuchiol in preparation of medicine for treating acute myocardial infarction
  • Application of bakuchiol in preparation of medicine for treating acute myocardial infarction
  • Application of bakuchiol in preparation of medicine for treating acute myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Experimental grouping

[0026] The experimental mice were randomly divided into 4 groups, respectively (1) sham operation group: implement sham operation and give placebo (5% sodium carboxymethyl cellulose) intragastric administration; (2) sham operation+drug group: implement sham operation Surgery and intragastric administration of 60 mg / kg / day bakuchiol; (3) surgery group: surgery and intragastric administration of placebo; (4) surgery + drug group: surgery and administration of 60 mg / kg / day bakuchiol intragastric administration. Part of the mice in the above four groups were administered intragastrically for 7 days according to the experimental requirements, and samples were taken after echocardiography for the next step of the experiment. experiment.

[0027] 2. Experimental results

[0028] (1) Bakuchiol improves the cardiac function of mice on the 7th day after myocardial infarction

[0029] After the establishment of the myocardial infarction model, contin...

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Abstract

The invention relates to application of bakuchiol in preparation of a medicine for treating acute myocardial infarction. It is proved that bakuchiol can inhibit proliferation, migration and differentiation of fibroblasts, improve early myocardial fibrosis and left ventricular remodeling after myocardial infarction and improve the ejection fraction and contractility of the heart, such that cardiac dysfunction after myocardial infarction can be improved; and it is prompted that the traditional Chinese medicine monomer bakuchiol may be a potential therapeutic drug for clinical treatment of acute myocardial infarction and is expected to become one of potential therapeutic measures for improving cardiac dysfunction of patients with acute myocardial infarction.

Description

technical field [0001] The invention belongs to the field of medicine, and particularly relates to the application of bakuchiol in the preparation of medicine for treating acute myocardial infarction. Background technique [0002] Myocardial infarction is already one of the leading causes of cardiac dysfunction, subsequent heart failure and death in patients worldwide. Cardiac remodeling plays an important role in coping with the structural disorder after myocardial infarction and maintaining the pumping function of the heart. Among them, in the gradual process of cardiac remodeling, the severity of myocardial fibrosis is closely related to the progressive development of heart failure, which can lead to the development of cardiac function from compensation to decompensation. Excessive fibrosis eventually leads to the development of heart failure; currently there is no effective clinical drug to reduce or reverse cardiac fibrosis. [0003] Cardiac fibroblasts play a crucial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K36/487A61P9/10A61P9/00
CPCA61K31/05A61K36/487A61P9/10A61P9/00
Inventor 沈竹夏王骏段云娇孙育民冯京夏盼盼黄挺顾慧慧巫雨恬
Owner 上海市静安区中心医院
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