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Conductive antibacterial composite hydrogel as well as preparation method and application thereof

A technology of composite hydrogel and conductive polyaniline, which is applied in the fields of pharmaceutical formulation, medical science, bandages, etc., can solve problems not involved in wound simulation and treatment, and achieve the transmission of electrical signals, good lubricity, and low antigen sexual effect

Pending Publication Date: 2021-12-31
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research and application of antibacterial hydrogel application did not involve the simulation and treatment of severe wound infection, which has always been one of the blind spots in the industry.

Method used

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  • Conductive antibacterial composite hydrogel as well as preparation method and application thereof
  • Conductive antibacterial composite hydrogel as well as preparation method and application thereof
  • Conductive antibacterial composite hydrogel as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0097] The present invention also provides a kind of preparation method of composite hydrogel, comprising the following steps:

[0098] 1) After polyvinyl alcohol, gelatin and water are mixed and dissolved, a mixed solution is obtained;

[0099] 2) Mixing the mixed solution obtained in the above steps, phytic acid, aniline, ammonium persulfate and water again, and freezing and removing impurities to obtain a conductive hydrogel;

[0100]3) The conductive hydrogel obtained in the above steps is soaked in water, and then placed in a silver nanoparticle solution to obtain a composite hydrogel.

[0101] In the present invention, polyvinyl alcohol, gelatin and water are first mixed and dissolved to obtain a mixed solution.

[0102] In the present invention, the mixing and dissolving temperature is preferably 80-90°C, more preferably 82-88°C, more preferably 84-86°C.

[0103] In the present invention, the mass ratio of polyvinyl alcohol to gelatin is preferably (0.05-2):1, more pr...

Embodiment 1

[0135] Preparation of Ag NPs

[0136] First, the prepared silver nitrate solution (0.1ⅹ10 -3 M, 97mL) was vigorously stirred at room temperature, and then 1mL sodium citrate solution (180ⅹ10 -3 M), 1mL PVP solution (4.2ⅹ10 -3 M), 240 μL H 2 o 2 solution (30wt%), and finally add 800 μL NaBH 4 solution (100ⅹ10 -3 M). After a few minutes, the solution rapidly completed the color change from a colorless solution, and the final color was dark blue, and the stirring continued for more than 2 hours. Finally, a stable bacteriostatic effect of 0.1ⅹ10 -3 The M / L silver nanoparticle solution is labeled for future use, and its nanoparticle morphology can be observed through a transmission electron microscope.

[0137] Characterize the silver nanoparticles prepared in the present invention.

[0138] see figure 1 , figure 1 TEM electron micrograph of silver nanoparticles prepared for the present invention.

[0139] Preparation of CPH

[0140] Take 0.25g of PVA and 0.075g of gel...

Embodiment 2

[0144] Performance testing was performed on the Ag NPs / CPH prepared in the present invention.

[0145] During the synthesis of Ag NPs / CPH, since PVA is the main substrate material, the effect of PVA reaction content on the mechanical properties of the prepared Ag NPs / CPH was first investigated.

[0146] Within a certain reaction concentration range (2.5-10wt%) of PVA in the Ag NPs / CPH can prepare hydrogels.

[0147] When a certain pressure is applied on the surface of hydrogels prepared with different reaction concentrations of PVA, the degree of hydrogel compression is similar. After the pressure is removed, the hydrogel returns to its initial state with little change in the macroscopic state.

[0148] The mechanical properties of hydrogels under different PVA concentrations were tested by using a universal material machine to test their tensile properties.

[0149] see figure 2 , figure 2 Mechanical property tests and physical deformation diagrams of Ag NPs / CPH prepare...

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Abstract

The invention provides composite hydrogel. The composite hydrogel comprises polyvinyl alcohol, gelatin, conductive polyaniline and silver nanoparticles; the polyvinyl alcohol, the gelatin and the conductive polyaniline form a cross-linked polymer network structure; and the silver nanoparticles are compounded in the polymer network structure. PVA and gelatin are used as a main matrix of the composite hydrogel, phytic acid is used as a cross-linking agent to introduce conductive polyaniline, and the hydrogel system is endowed with conductive performance; meanwhile, a physical cross-linked 3D polymer network structure is formed, and the antibacterial performance of a hydrogel dressing is improved in combination with the silver nanoparticles. The material has good mechanical properties, conductivity, biological capacity and antibacterial activity, still has a good effect of promoting wound healing, comprising the effect of promoting generation of blood vessels, skin cells, hair follicles and the like, on wounds which are infected with bacteria for a period of time and are heavily infected, and is a medical hydrogel dressing with great application potential.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and relates to a composite hydrogel and its preparation method and application, in particular to a medical conductive antibacterial composite hydrogel and its preparation method and application. Background technique [0002] Wound infection usually refers to a relatively serious inflammatory reaction after microorganisms invade the damaged skin for a long time (more than 24 hours). The clinical manifestations are local redness and swelling, pain, pus oozing, peculiar smell, etc., and severe cases can cause systemic infection, and even threaten people's lives. Therefore, healing infected wounds and accelerating their healing has high clinical significance. Traditional dressings, such as gauze and bandages, have good air permeability, but obviously cannot play an antibacterial effect on infected wounds. And in the course of treatment, it is easy to cause wound adhesion to cause secondar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L29/04C08L89/00C08L79/02C08K3/08A61L26/00
CPCC08J3/075A61L26/0014A61L26/0038A61L26/0019A61L26/0004A61L26/0066A61L26/008A61L26/0061C08J2329/04C08J2379/02C08J2489/00C08K2003/0806A61L2300/104A61L2300/404A61L2400/12C08L29/04C08L89/00C08L79/02
Inventor 姜英男匡玉兰闫茹月赵新宇田腾辉张哲王继凤肖利智孙天霞朱迪夫
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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