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Application of coptis chinensis in preparation of product for promoting proliferation of intestinal beneficial bacteria

A technology for beneficial bacteria and intestinal flora imbalance, applied in the field of microorganisms, can solve problems such as no related reports, and achieve the effect of broadening the application field, promoting the proliferation of intestinal beneficial bacteria, and efficiently preparing

Pending Publication Date: 2022-01-28
MEI YI TIAN BIOLOGICAL MEDICINE WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the composition of Coptidis rhizome plays a role in regulating the human gastrointestinal microbiota and treating dysbacteriosis, and there is no relevant report so far.

Method used

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  • Application of coptis chinensis in preparation of product for promoting proliferation of intestinal beneficial bacteria
  • Application of coptis chinensis in preparation of product for promoting proliferation of intestinal beneficial bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] Carry out in vivo simulation experiments in vitro, take human feces as intestinal flora samples, and observe the intervention effect of Coptis chinensis on intestinal flora. The specific operation process is as follows:

[0042] 1. Fecal sample processing

[0043] 10 g of stool samples were prepared with PBS buffer solution to a final concentration of 5%, and the mixed samples were sequentially passed through 20 mesh, 50 mesh, 100 mesh, and 200 mesh filters. Collect the filtrate into a centrifuge tube, put the centrifuge tube into a centrifuge, balance, centrifuge at 6000G, 4°C for 15min, and discard the supernatant. After the precipitate was weighed, the final concentration was 5% with PBS solution to obtain the intestinal microbial sample.

[0044] Wherein, the composition of PBS buffer comprises by concentration: KH 2 PO 4 0.24g / L, Na 2 HPO 4 12H 2 O 2.90g g / L, NaCl 8.00g g / L, KCl 0.20g g / L.

[0045] 2. Coptis chinensis intervention experiment

[0046] (1) P...

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PUM

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Abstract

The invention provides application of coptis chinensis in preparation of a product for promoting proliferation of intestinal beneficial bacteria, and relates to the technical field of microorganisms. According to the application, an intestinal environment is simulated in vitro, an intestinal flora collected from faeces of a healthy human body is taken as a sample, and research finds that coptis chinensis can significantly promote proliferation of intestinal beneficial bacteria, especially has an extremely significant effect of promoting proliferation of intestinal beneficial bacteria such as bifidobacterium and Arrisonia; the invention further provides application of coptis chinensis in preparation of drugs for treating or improving diseases caused by intestinal flora imbalance. Particularly, the coptis chinensis can be applied to a method for directionally fermenting the specific donor flora for coprophilous fungus transplantation, so that the specific donor flora beneficial to the intestinal tract is directionally fermented, and the specific donor flora can enter the gastrointestinal tract of a patient through coprophilous fungus transplantation to reconstruct a new intestinal flora, so that the treatment of intestinal and extraintestinal diseases is realized; scientific basis is provided for clinical application, and the application field of coptis chinensis is expanded.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to the application of Coptis Rhizoma in the preparation of products for promoting the proliferation of intestinal beneficial bacteria. Background technique [0002] Coptidis is a traditional Chinese medicine, containing berberine, and contains coptisine, methyl coptisine, palmatine, berberine, epiberberine, coptisine, palmatine, jatrorrhizine and so on. The authenticity of Coptis chinensis can be identified by proton nuclear magnetic resonance spectroscopy. Berberine is the main active ingredient in coptis. [0003] The main function of Coptis chinensis is to clear away heat and dampness, relieve fire and detoxify. Used for: Damp-heat fullness, vomiting and acid regurgitation, dysentery, jaundice, high fever and coma, hyperactivity of heart-fire, upset and insomnia, vomiting of blood heat, red eyes, toothache, quenching thirst, carbuncle and sore; external treatment Eczema...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P1/00A61P29/00A61P35/00A61P25/00A23L33/10C12N1/38C12N1/20C12R1/01
CPCA61K36/718A61P1/00A61P29/00A61P35/00A61P25/00A23L33/10C12N1/38C12N1/20A23V2002/00A23V2200/3204
Inventor 刘庆军沈鹤霄李国龙张帆刘慧敏熊云吕永玲彭文聪
Owner MEI YI TIAN BIOLOGICAL MEDICINE WUHAN CO LTD
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