Unlock instant, AI-driven research and patent intelligence for your innovation.

Neuroprotective drug SS31-HA-QT targeting mitochondria in cerebral ischemic region as well as fluorescent probe and application of neuroprotective drug SS31-HA-QT

A technology for neuroprotection and cerebral ischemia, applied in drug combinations, nervous system diseases, preparations for in vivo experiments, etc., can solve the problems of significant first-pass effect, limited neuroprotective effect, low bioavailability, etc., and achieve good results Effect against cerebral ischemia

Active Publication Date: 2022-01-28
HENAN UNIVERSITY
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its neuroprotective effect is limited due to its poor water solubility, significant first-pass effect, low bioavailability after oral administration, and the restriction of the blood-brain barrier to the drug entering the brain.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Neuroprotective drug SS31-HA-QT targeting mitochondria in cerebral ischemic region as well as fluorescent probe and application of neuroprotective drug SS31-HA-QT
  • Neuroprotective drug SS31-HA-QT targeting mitochondria in cerebral ischemic region as well as fluorescent probe and application of neuroprotective drug SS31-HA-QT
  • Neuroprotective drug SS31-HA-QT targeting mitochondria in cerebral ischemic region as well as fluorescent probe and application of neuroprotective drug SS31-HA-QT

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0061] The preparation method of the neuroprotective drug SS31-HA-QT targeting the mitochondria in the cerebral ischemic region and its fluorescent probe in this example:

[0062] HA-QT synthesis and characterization, its technical route is as follows figure 1 Shown: Accurately weigh 0.379g HA (1mmol), dissolve in 4mL double distilled water, add 0.767g activator EDC·HCl (4mmol) to activate for 2h. 0.453g QT (1.5mmol) was dissolved in 3ml DMF, and placed in an ice bath for 10min precooling. The QT solution was added dropwise to the HA solution, and reacted for 12 h under the protection of argon. Impurities were removed by dialysis, and the dialysate was double distilled water. The final reaction solution was filtered with a microporous membrane (0.45 μm) and freeze-dried to obtain a final product of 0.384 g HA-QT (yield 90%, QT grafting rate 13%).

[0063] SS-31-HA-QT synthesis and characterization, its technical route is as follows figure 1 Shown: Accurately weigh 0.108g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of biological pharmacy, and relates to a drug for targeting mitochondria in a cerebral ischemic region, and in particular relates to a neuroprotective drug SS31-HA-QT for targeting mitochondria in the cerebral ischemic region as well as a fluorescent probe and application of the neuroprotective drug SS31-HA-QT. According to the invention, QT is grafted onto HA through a chemical synthesis method to synthesize HA-QT, SS31 is grafted onto HA to synthesize SS31-HA-QT, and in vivo and in vitro experiments prove that the compound has a good cerebral ischemia resistance effect. Furthermore, with the help of fluorescent probes IR780-HA-QT and IR780-SS31-HA-QT for synthesizing HA-QT and SS31-HA-QT, the ability of the drug to penetrate through a blood brain barrier and enter damaged neurons is verified, and the efficacy of the drug in targeting a focus area is proved.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to a drug targeting mitochondria in cerebral ischemic regions, in particular to a neuroprotective drug SS31-HA-QT targeting mitochondria in cerebral ischemic regions, a fluorescent probe and applications thereof. Background technique [0002] Cerebral ischemia refers to a neurological disease in which blood flow in brain tissue is reduced or interrupted due to hemorrhage or ischemia, resulting in dysfunction of vascular endothelial cells and nerves. It has the characteristics of high incidence, disability, and mortality. The main symptoms are sudden loss of consciousness, insomnia, language barrier, etc. The early stages of cerebral ischemia are mainly multi-molecular and organelle damage mediated by oxidative stress. However, Edaravone, the only clinically approved effective free radical scavenger, has poor long-term effects, and improper use will further aggravate ischemic damage. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/61A61K47/64A61K31/352A61P25/00A61P9/10A61P39/06A61K49/00C09K11/06C08B37/08
CPCA61K47/61A61K47/64A61K31/352A61P25/00A61P9/10A61P39/06A61K49/0021A61K49/0054C09K11/06C08B37/0072C09K2211/145
Inventor 岑娟段少峰李肖寒张欣张润芳
Owner HENAN UNIVERSITY
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com