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Composition mucosa preparation for relieving muscae volitantes as well as preparation method and application of composition mucosa preparation

A composition and technology of floaters, applied in the medical and health field, achieves the effects of simple preparation process, improved treatment compliance, and obvious therapeutic significance

Inactive Publication Date: 2022-02-08
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to treat the problem of floaters caused by lipidation of blood vessels in the fundus, and to provide a night-time effective period of 6-8 hours, which releases the mucous membrane of notoginseng saponin microcapsules and nicotinamide mononucleotide complex according to a certain rule. Formulation and its preparation method

Method used

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  • Composition mucosa preparation for relieving muscae volitantes as well as preparation method and application of composition mucosa preparation
  • Composition mucosa preparation for relieving muscae volitantes as well as preparation method and application of composition mucosa preparation
  • Composition mucosa preparation for relieving muscae volitantes as well as preparation method and application of composition mucosa preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 10

[0041] Example 1 Preparation of Notoginsenoside Microcapsules and Nicotinamide Mononucleotide Compound External Transdermal Absorbent

[0042] 1. Preparation of external transdermal absorbent compounded with notoginseng saponin microcapsules and nicotinamide mononucleotide

[0043] (1) Preparation of notoginsenoside molecular microcapsules

[0044] Prescription: Panax notoginseng saponins: soybean lecithin: cholesterol (w / w / w) = 2:8:1

[0045] Preparation steps:

[0046] Dissolve 25mg of notoginseng saponin powder in 5ml of phosphate buffer solution (pH6.8) as the water phase. Dissolve 100mg of soybean lecithin and 12.5mg of cholesterol in 40ml of chloroform to dissolve completely, transfer to a rotary evaporator, remove the organic solvent by rotary evaporation at 25°C, and control the rotation speed of the rotary evaporator at the same time, so that the lipid is in a circle A layer of uniform film is formed on the bottom flask wall, after drying for 24 hours, add the buff...

Embodiment 2 10

[0057] Example 2 Preparation of Pilot Product of Notoginseng Saponin Microcapsules and Nicotinamide Mononucleotide Composite Transdermal Absorbent for External Use (Three Batches)

[0058] According to the method of Example 1 (1), the prescription in Table 2 was prepared into three batches of a pilot product of external transdermal absorbent compounded with notoginseng saponin microcapsules and nicotinamide mononucleotide, 100 parts / batch.

[0059] Table 1

[0060]

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Abstract

The invention discloses a notoginsenoside and nicotinamide mononucleotide composite external transdermal absorbent and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The notoginsenoside and nicotinamide mononucleotide composite external transdermal absorbent is prepared by the steps: adding notoginsenoside molecular microcapsules into a blank matrix in an equivalent progressive increase manner, uniformly dispersing, adding corresponding nicotinamide mononucleotide according to a ratio, adding a humectant, an emulsifier and a penetration enhancer, uniformly stirring, adding a pH regulator, and adjusting the pH value to 6-7. The notoginsenoside and nicotinamide mononucleotide composite external transdermal absorbent provided by the invention is strong in compound medication curative effect, can avoid the defects of low bioavailability, strong irritation and the like caused by an existing medicine, has the characteristics of good absorbability, strong stability, no irritation and the like, overcomes the defect that notoginsenoside is difficult to absorb transdermally due to large molecular weight, and achieves the purpose of treating muscae volitantes through external application of notoginsenoside.

Description

technical field [0001] The invention belongs to the field of medical and health care, and in particular relates to a composition for relieving floaters, its preparation and its application, especially relates to the compound use of notoginseng saponin and nicotinamide mononucleotide which can promote blood circulation and remove blood stasis, so that the fundus blood vessels Fatty form is reduced, thereby fundamentally solving the state of floaters caused by blood lipid stickiness. The preparation formed by the composition has the characteristics of simple preparation method, safe and convenient use. Background technique [0002] Floaters are a type of disease characterized clinically by dark shadows floating in front of the eyes accompanied by vision loss. Floaters are a common disease in ophthalmology, and its patients are mostly middle-aged and elderly people over 40 years old. With the development of society and the acceleration of the pace of life, people's life press...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/52A61K47/32A61K47/24A61K47/28A61K31/706A61K31/704A61P27/02
CPCA61K9/7023A61K47/32A61K9/5015A61K9/5089A61K9/0014A61K9/0048A61K31/706A61K31/704A61P27/02A61K2300/00
Inventor 金青郝小惠陈永根刘兴华李微微赵文英谭心舜彭佳
Owner QINGDAO UNIV OF SCI & TECH