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Sustained-release formulation of matrine microcapsule gel composite system and its preparation method and application

A slow-release preparation, the technology of matrine, applied in the field of pesticides, can solve the problems of accumulation in the roots of chives, pollution, poisoning environment, etc., and achieve the effects of less environmental pollution, obvious economic benefits, and productivity saving

Active Publication Date: 2020-06-23
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the problems that the existing insecticides are easy to accumulate in the roots of leeks, causing poisoning and environmental pollution, and to provide a kind of long-term effective period that basically covers a harvest period of leeks, and releases matrine according to a certain rule, which is safe. Microcapsule gel complex system sustained-release preparation and preparation method thereof

Method used

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  • Sustained-release formulation of matrine microcapsule gel composite system and its preparation method and application
  • Sustained-release formulation of matrine microcapsule gel composite system and its preparation method and application
  • Sustained-release formulation of matrine microcapsule gel composite system and its preparation method and application

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preparation example Construction

[0036] On the other hand, the present invention also provides a method for preparing the slow-release preparation of the botanical pesticide matrine microcapsule gel composite system, comprising the following process steps:

[0037] (1) Mix egg white and deionized water evenly to obtain egg white solution;

[0038] (2) matrine is dissolved in ethanol to obtain matrine ethanol solution;

[0039] (3) Add the matrine ethanol solution obtained in step (2) dropwise to the egg white solution in step (1), after forming a uniform mixture, centrifuge, discard the supernatant, and freeze-dry the lower layer to obtain microcapsules;

[0040] (4) Disperse the microcapsule particles into the gel by equal volume addition method.

[0041] In a preferred embodiment of the present invention, the concentration of the egg white solution is 75%-85%. In a preferred embodiment of the present invention, the concentration of the egg white solution is 80%.

[0042] In a preferred embodiment of the...

Embodiment 1

[0048] according to figure 1 The cumulative release curve of the compound sustained-release preparation fits the first-order kinetic equation model, Q=94.1502(1-e -0 . 5655n ), r=0.9997, where Q represents the cumulative drug release rate (%), n represents the number of times of application (times), and e is a natural constant. Calculated according to the longest period of a leek harvest period of 24 days (on average, irrigate once every 3 days, 0.5h each time), the minimum release rate accounts for 2.39% of the total input amount. In the field effect experiment, matrine The effective dose is 22g / mu (referring to Wu Chuanwan's "Plant Source Pesticide Matrine Controlling Chive Maggots Test"), so as to determine the standard prescription for each dosing point as follows:

[0049] Main drug (matrine) 837mg

[0050] 80% ethanol solution 42mL

[0051] 80% egg white solution 100mL

[0052]1% Carbomer 941 25mL

[0053] The preparation steps of the gel composite system are as fo...

Embodiment 2

[0062] Time: 2017.5.10-2017.6.4

[0063] Location: Vegetable greenhouse in Tanjiafang Town, Qingzhou City, Shandong Province

[0064] Application method: according to 667m per mu 2 (25.83m*25.83m) calculation, set a dosing point about every 5 meters, the distribution of dosing points is as follows image 3 As shown, the main drug dose at each application point is 0.837 mg, and the application is carried out at a depth of 3 to 4 cm underground. Watering is performed every 3 days, and the application time is set to start after the leeks have been harvested.

[0065] Control group: phoxim seed dressing. Commercially available 40% phoxim emulsifiable concentrate (pesticide registration certificate number: PD85157-2) was applied once every 3 days, and 60 mL per mu was used as a control.

[0066] The other field managements of the embodiment group and the control group are the same.

[0067] result:

[0068] The embodiment group sprayed once, watered once every three days, no c...

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Abstract

The invention belongs to the technical field of pesticide, and more specifically relates to a plant-source pesticide matrine microcapsule gel combined system sustained release preparation, and a preparation method thereof. The matrine microcapsule gel combined system sustained release preparation comprises gel, and microcapsule particles dispersed in the gel; egg white is taken as a capsule material of the microcapsule particles, and matrine is taken as an effective component. The preparation method comprises following steps: egg white is uniformly mixed with deionized water so as to obtain anegg white solution; matrine is dissolved in ethanol so as to obtain a matrine ethanol solution; the matrine ethanol solution is added into the egg white solution drop by drop so as to obtain a uniform mixture; the uniform mixture is subjected to centrifugation so as to remove an upper layer supernatant; an lower layer precipitate is subjected to freeze drying so as to obtain the microcapsule particles; and the microcapsule particles are dispersed in the gel via equal amount progressive increasing method so as to obtain the plant-source pesticide matrine microcapsule gel combined system sustained release preparation. The release rules of medical ingredients of the plant-source pesticide matrine microcapsule gel combined system sustained release preparation are obvious, effect lasting period is as long as the leek harvesting period, and the preparation method is simple.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to a slow-release preparation of a botanical pesticide matrine microcapsule gel composite system and a preparation method thereof. Background technique [0002] Chive maggot is a kind of agricultural and forestry pest that seriously harms the growth and yield of leek, and its harmfulness ranks first among the pests of leek. The commonly used radical treatment method is to use phoxim seed dressing to eliminate pests, but this leads to the accumulation of pesticides in the roots, and poisonous leek incidents occur frequently. Poisoning occurred afterwards. Simultaneously, the use of chemical pesticides can also cause environmental pollution, so seeking a pesticide that can kill leek maggots in an effective dose without causing pesticide residues and food safety has become a top priority. According to literature reports, the natural matrine extracted from the roots of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/28A01N25/04A01P7/04
Inventor 金青赵文英齐娟王瑞玉谭心舜
Owner QINGDAO UNIV OF SCI & TECH