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Micro-needle patch for acne removal and repair, and preparation method and application thereof

A technology of micro-needle sticking and acne removal, which is applied in skin care preparations, micro-needles, cosmetic preparations, etc. It can solve the problems of insufficient anti-inflammatory and acne-removing effects, achieve good acne-removing and repairing effects, and shorten acne Cycle, Pigmentation Reduction Effect

Pending Publication Date: 2022-02-11
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are not many relevant reports on the market that microneedles containing recombinant collagen can achieve better anti-inflammatory and anti-acne effects

Method used

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  • Micro-needle patch for acne removal and repair, and preparation method and application thereof
  • Micro-needle patch for acne removal and repair, and preparation method and application thereof
  • Micro-needle patch for acne removal and repair, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A microneedle patch for acne repair, comprising a base and a needle tip loaded with an active ingredient, the active ingredient includes the following components by weight:

[0032] Sodium hyaluronate 5.0g, recombinant collagen 1.0g, azelaic acid 1.0g, salicylic acid 0.5g, tetrahydromethyl pyrimidine carboxylic acid 0.2g and dipotassium glycyrrhizinate 0.2g.

[0033] The preparation method of the above-mentioned microneedle patch for acne repairing comprises the following steps:

[0034] 1) Weigh the above-mentioned components according to the proportion, dissolve the components with purified water at room temperature, use a homogeneous mixer to homogeneously mix and prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm. Time is 10min, detect the pH value of the solution;

[0035] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold, scrape and coat it, then put the poly...

Embodiment 2

[0037] A microneedle patch for acne repair, comprising a base and a needle tip loaded with an active ingredient, the active ingredient includes the following components by weight:

[0038] Sodium hyaluronate 2.5g, recombinant collagen 0.5g, azelaic acid 0.5g, salicylic acid 0.2g, tetrahydromethyl pyrimidine carboxylic acid 0.3g and dipotassium glycyrrhizinate 0.1g.

[0039] The preparation method of the above-mentioned microneedle patch for acne repairing comprises the following steps:

[0040] 1) Weigh the above-mentioned components according to the proportion, dissolve the components with purified water at room temperature, use a homogeneous mixer to homogeneously mix and prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm. Time is 10min, detect the pH value of the solution;

[0041] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold, scrape and coat it, then put the poly...

Embodiment 3

[0043] A microneedle patch for acne repair, comprising a base and a needle tip loaded with an active ingredient, the active ingredient includes the following components by weight:

[0044] Sodium hyaluronate 7.5g, recombinant collagen 1.0g, azelaic acid 1.0g, salicylic acid 0.5g, tetrahydromethyl pyrimidine carboxylic acid 0.1g and dipotassium glycyrrhizinate 0.2g.

[0045] The preparation method of the above-mentioned microneedle patch for acne repairing comprises the following steps:

[0046] 1) Weigh the above-mentioned components according to the proportion, dissolve the components with purified water at room temperature, use a homogeneous mixer to homogeneously mix and prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm. Time is 10min, detect the pH value of the solution;

[0047] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold, scrape and coat it, then put the poly...

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Abstract

The invention relates to the technical field of cosmetic beauty, and particularly discloses a microneedle patch for acne removal and repair, and a preparation method and application thereof. The micro-needle patch for acne removal and repair comprises a substrate and a needle tip loaded with active ingredients, and the active ingredients comprise, by weight, 2.5 to 7.5 parts of sodium hyaluronate, 0.5 to 1.5 parts of recombinant collagen, 0.5 to 1.5 parts of azelaic acid, 0.2 to 0.8 part of salicylic acid, 0.1 to 0.3 part of tetrahydromethylpyrimidine carboxylic acid and 0.1 to 0.3 part of dipotassium glycyrrhizinate. The needle tip containing the sodium hyaluronate can pierce the skin cuticle to form a micro-channel, the sodium hyaluronate can absorb tissue fluid of the skin to be dissolved at the same time, and then the active components are delivered to the subcutaneous part, so that the active components staying under the subcutaneous part have a good acne removing and repairing effect on the skin, the acne period can be greatly shortened, hyperpigmentation is reduced, and acne marks are repaired.

Description

technical field [0001] The invention relates to the technical field of cosmetics and cosmetics, in particular to a microneedle patch for acne repair and its preparation method and application. Background technique [0002] As a method for effective drug delivery of various medicines applied to the human body, a method of injecting medicines in a liquid form through a hypodermic needle is widely used. However, a hypodermic needle with a diameter of about several millimeters irritates many pain points existing in the skin, thereby causing pain to the patient. Compared with traditional hypodermic needle drug delivery, microneedles (MNs) are small in size, and the length of the needle is usually less than 1 mm. Due to their micron-scale size, MNs can seamlessly pierce the stratum corneum of the skin and form microscopic lesions on the skin surface. channel, and the active macromolecules (including therapeutic molecules with a wide range of molecular weights, such as small molec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/362A61K8/368A61K8/49A61K8/63A61K8/65A61K8/02A61M37/00A61P17/10A61Q19/00A61Q19/02
CPCA61K8/735A61K8/65A61K8/362A61K8/368A61K8/4953A61K8/63A61K8/0204A61Q19/00A61Q19/02A61P17/10A61M37/0015A61K2800/91A61M2037/0053A61M2037/0046
Inventor 郭瑞黄尚辉刘玉
Owner BEOGENE BIOTECH GUANGZHOU