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Novel application of sodium benzoate

A sodium benzoate, behavioral technology, applied in the field of medicine, can solve different problems

Inactive Publication Date: 2022-02-25
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although autism, schizophrenia, and depression are both diseases of the central nervous system, the social behavior of autistic patients is different from that of schizophrenia, depression and other mental diseases. The application of sodium benzoate in the treatment of autism still unreported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of mouse autism model by polyinosinic acid injection during pregnancy

[0023] Pregnancy 12.5 days female mice were randomly divided into experimental group and control group, polyinosine-cytidine (Poly I:C) product of Sigma Company of the United States was dissolved and diluted to 20mg / kg with normal saline, and administered once intraperitoneal injection, the control group was given intraperitoneal injection of sterile PBS.

[0024] Such as figure 1 As shown, three hours after Poly I:C injection, the expression of IL-6 gene in the spleen of pregnant mice increased sharply (P figure 1 A). The pregnant mice after Poly I:C injection showed a significant decrease on the second day (P figure 1 B). For the behavioral experiment of male offspring at 8-12 weeks, the scores of offspring mice produced by pregnant mice in Poly I:C injection group were significantly higher than those in the control group mice in the bead burying test (P figure 1 C), showi...

Embodiment 2

[0025] Example 2 The improvement effect of oral sodium benzoate on the social behavior of poly I:C-induced autistic mice

[0026] The male mice of the 3-week-old Poly I:C modeling group and the PBS control group were randomly divided into 4 groups:

[0027] Modeling group (PIC): male offspring mice were treated with PBS after weaning at 3 weeks old. PBS 0.22um equivalent to sodium benzoate was sterilized by filtration and added to the drinking water of mice.

[0028] Modeling group + sodium benzoate treatment group (PIC + Nab): male offspring were treated with sodium benzoate after weaning at 3 weeks old. Sodium benzoate, produced by Shanghai Macklin Biochemical Technology Co., Ltd., was dissolved in PBS before use, sterilized by 0.22um filter and added to the drinking water of mice. Maintain the final concentration of sodium benzoate at 5 mg / ml.

[0029] Control group (PBS): The male offspring mice were treated with PBS after weaning at the age of 3 weeks. PBS 2.22um equi...

Embodiment 3

[0039] Example 3 Effect of Oral Sodium Benzoate on Poly I:C-Induced Autism Mouse Brain Functional Connectivity

[0040] The male mice of the 3-week-old Poly I:C modeling group and the PBS control group were randomly divided into 4 groups:

[0041] Modeling group (PIC): male offspring mice were treated with PBS after weaning at 3 weeks old. PBS 0.22um equivalent to sodium benzoate was sterilized by filtration and added to the drinking water of mice.

[0042] Modeling group + sodium benzoate treatment group (PIC + Nab): male offspring were treated with sodium benzoate after weaning at 3 weeks old. Sodium benzoate, produced by Shanghai Macklin Biochemical Technology Co., Ltd., was dissolved in PBS before use, sterilized by 0.22um filter and added to the drinking water of mice. Maintain the final concentration of sodium benzoate at 5 mg / ml.

[0043] Control group (PBS): The male offspring mice were treated with PBS after weaning at the age of 3 weeks. PBS 2.22um equivalent to ...

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Abstract

The invention discloses novel application of sodium benzoate. The invention relates to the application of sodium benzoate in preparation of medicine for improving social behaviors and / or engraving behaviors of autism patients. According to the invention, it is found that sodium benzoate can improve the autism-like behavior of a filial generation mouse caused by maternal immune activation, especially improve the social behavior of a model mouse. In a bead embedding experiment, the score of the filial-generation model mice is reduced (wherein P is less than 0.001) after the filial-generation model mice are treated by sodium benzoate, and repeated engraving tendency is relieved; in a three-box social experiment, the social contact time of the filial-generation model mice is relatively prolonged compared with the social contact time of the same kind after the filial-generation model mice are treated by sodium benzoate; and therefore, the sodium benzoate can be used for preparing the medicine for improving the social behavior of an autism patient.

Description

technical field [0001] The invention belongs to the field of medicines and relates to a new application of sodium benzoate, in particular to the application of sodium benzoate in the preparation of medicines for improving social behavior and / or stereotyped behavior of autistic patients. Background technique [0002] Autism, also known as autism (Autistic Spectrum Disorder, ASD), is a serious neurodevelopmental disorder. Autism, also known as autism, autistic disorder, etc., is a representative disease of pervasive developmental disorder (PDD). , delayed language development, etc. Autism seriously affects human life and health, with a high disability rate and heavy social burden. In addition to the above three core symptoms, some children are also accompanied by gastrointestinal symptoms such as constipation and diarrhea, and even severe mental retardation and developmental delay. At present, the pathogenesis and reliable biomarkers of ASD are still unclear, which makes it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P25/00
CPCA61K31/192A61P25/00
Inventor 刘星吟李涛
Owner NANJING MEDICAL UNIV
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