Diffuse large B-cell lymphoma prognosis model based on MYC/BCL2 double expression and immune microenvironment, application and prognosis method

A diffuse, B-cell technology, applied in the fields of biology and medical testing, can solve problems such as rapid recurrence and poor prognosis, and achieve the effect of precise stratified treatment

Pending Publication Date: 2022-02-25
CANCER CENT OF GUANGZHOU MEDICAL UNIV
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Problems solved by technology

[0005] With the application of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), the overall survival rate of DLBCL can reach 60%, and the clinical efficacy of DLBCL is increasing day by day. However, there are still patients who do not respond to treatment or relapse rapidly after treatment, the disease progresses rapidly, and the prognosis is poor

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  • Diffuse large B-cell lymphoma prognosis model based on MYC/BCL2 double expression and immune microenvironment, application and prognosis method
  • Diffuse large B-cell lymphoma prognosis model based on MYC/BCL2 double expression and immune microenvironment, application and prognosis method
  • Diffuse large B-cell lymphoma prognosis model based on MYC/BCL2 double expression and immune microenvironment, application and prognosis method

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[0045] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0046] Explanation of terms involved in the present invention:

[0047] DLBCL (Diffuse Large B-Cell Lymphoma): diffuse large B-cell lymphoma;

[0048] FISH (Fluorescence in situ hybridization): Fluorescence in situ hybridization technology is an important non-radioactive in situ hybridization technology. According to the principle of complementary base pairing, probes with fluorescent substances are combined with target DNA by special means, and finally The location of the target DNA can be directly observed with a fluorescence microscope.

[0049] Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma with high clinical and biological het...

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Abstract

The invention discloses a diffuse large B-cell lymphoma prognosis model based on MYC / BCL2 double expression and an immune microenvironment, application and a prognosis method. Based on the MYC / BCL2 protein expression level and the immune microenvironment, the MYC / BCL2 protein expression level and the immune microenvironment synergistically play a unique role in prognosis of various DLBCL subtype patients, assist clinicians in judging clinical development and disease outcome of the patients, and realize precise layered treatment.

Description

technical field [0001] The invention belongs to the technical field of biology and medical examination, and specifically relates to a diffuse large B-cell lymphoma prognosis model, application and prognosis method based on MYC / BCL2 double expression and immune microenvironment. Background technique [0002] Diffuse Large B-Cell Lymphoma (DLBCL) is currently the most common adult non-Hodgkin's lymphoma, and it is a highly aggressive and rapidly growing tumor. Studies have shown that DLBCL has high heterogeneity in pathomorphology, immunological phenotype, gene expression, etc., and more and more evidence shows that it may not be a truly independent disease. [0003] Traditional methods for evaluating the prognosis of DLBCL patients mainly rely on clinical parameters, the most commonly used is the international prognostic index (IPI), including age, functional status, serum lactate dehydrogenase level, the number of extranodal sites involved, and AnnArbor stage, etc. 5 clinic...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886G01N33/57407G01N33/56972C12Q2600/118C12Q2600/158G01N2800/52G01N2800/60
Inventor 游华
Owner CANCER CENT OF GUANGZHOU MEDICAL UNIV
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