Preparation method of sustained-release granules
A slow-release granule and slow-release technology, applied in the field of medical drugs, can solve the problem that traditional Chinese medicine cannot be absorbed in the small intestine, and achieve the effect of improving the use effect
Pending Publication Date: 2022-03-01
成都市坤宏优创动物科技有限公司
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Problems solved by technology
[0004] The purpose of the present invention is to provide a sustained-release method for the problem that the main part of the absorption of some drugs is in the small intestine, but most of the particles of the Chinese medicine extract precipitate in the stomach, so that the Chinese medicine cannot be absorbed in the small intestine. Granule preparation method
Method used
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Embodiment 1
[0028] Example 1: See figure 1 Distance
[0029] The method for preparing a sustained release particle provided in this embodiment, wherein the sustained release granules comprise a Chinese medicine extract, a comprise, a binder, a sustained release material, a buffer, the sustained release granules in accordance with The following steps are made:
[0030] Step 1, adding a composite: Add the comprise to the extract to sustained release of the extract;
[0031] Step 2, granulation: Add the adhesive to the composition to obtain the binder to add the adhesive to the composition, and the granulation is carried out;
[0032] Step three, add a sustained release material: In the particulate matter obtained by the second step, the bundled material is added, and the sustained release material is used to sustained release of the particulate matter;
[0033] Step 4, add buffer: Adding a buffer in the particulate matter added to the sustained release material obtained in the step three, the b...
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The invention relates to the technical field of medical treatment, in particular to a preparation method of sustained-release granules, which comprises the following steps that: the sustained-release granules comprise a traditional Chinese medicine extract, a clathrate compound, an adhesive, a sustained-release material and a buffering agent, and the sustained-release granules are prepared according to the following steps: step 1, adding the clathrate compound: adding the clathrate compound on the basis of the extract, the clathrate compound has a slow release effect on the extract. And step 2, adding an adhesive: adding the adhesive, so that the sustained-release particles are kept granular. And step 3, adding a sustained-release material: adding the sustained-release material to further improve the sustained-release effect of the sustained-release particles. And step 4, adding a buffering agent, wherein the buffering agent reacts with gastric acid in the stomach to further improve the slow-release effect of the slow-release particles. And 5, verification test: verifying the slow-release effect of the slow-release particles according to the medicines added in the above step.
Description
Technical field [0001] The present invention relates to the technical field of medical pharmaceutical, and more particularly to a process for sustained release particles. Background technique [0002] Slip-release drugs are also known as the sustained release formulation, refers to the preparation of the drug released in the predetermined release medium, and compared with the corresponding common formulation, the administration frequency is at least reduced in accordance with the corresponding ordinary preparation, and can significantly increase the patient's compliance. Sex or reduce the side effects of drugs. [0003] Most Chinese medicine extracts precipitate under acidic conditions (such as baicin extracting precipitation of pH for 1-2, completely dissolved pH is 5.0 or more) However, the stomach pH of the single stomach animal is 1-2, general extract is suitable The pH is 5-7, and the main part of the drug absorbed in the small intestine, the pH of the small intestine sectio...
Claims
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IPC IPC(8): A61K9/16A61K47/69A61K47/36A61K47/38A61K47/12A61K47/32A61K47/22A61K47/02A61K31/7048
CPCA61K9/1652A61K9/1635A61K9/1617A61K9/1611A61K31/7048
Inventor 王建军
Owner 成都市坤宏优创动物科技有限公司