Lens injury inhibitor based on Keap1-Nrf2 signaling pathway

Abstract

The invention discloses a crystalline lens injury inhibitor based on a Keap1-Nrf2 signal channel, and belongs to the field of crystalline lens injury inhibition, the crystalline lens injury inhibitor contains mitochondrial targeting peptide, can inhibit crystalline lens injury, especially epithelial cell injury, through the Keap1-Nrf2 signal channel, can improve the oxidative stress level and cell viability in LECs, and can inhibit crystalline lens injury, especially epithelial cell injury, through the Keap1-Nrf2 signal channel. Compared with the prior art, the compound provided by the invention has the advantages of improving the inhibition effect on oxidative stress-induced apoptosis, having potential benefits, having no obvious toxic and side effects, having good clinical application prospects, and providing important theoretical and practical basis for clinical diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of lens damage inhibition, more specifically, relates to a lens damage inhibitor based on the Keap1-Nrf2 signaling pathway. Background technique [0002] The World Health Organization report pointed out that cataract is the world's first blinding eye disease. The results of the "Age-Related Eye Disease Study" released by the National Institute of Ophthalmology (NIH) pointed out that cataracts are the leading cause of vision loss and blindness. question. [0003] At present, there is no effective way to prevent the occurrence and development of cataract in the world. Cataract surgery is still the first choice for the treatment of cataract. However, surgery still has certain risks and brings obvious economic and psychological burdens to patients, and increases huge expenditures to the society. Especially in remote mountainous areas and underdeveloped areas in my country, factors such as expensive surgical equipment and...

AI Technical Summary

Problems solved by technology

[0003] At present, there is no effective way to prevent the occurrence and development of cataract in the world. Cataract surgery is still the first choice for the treatment of cataract. However, surgery still has certain risks and brings obvious economic and psychological burdens to patients, and increases huge expenditures to the society. Especially in remote mountainous areas and underdeveloped areas in my country, factors such as expensive surgical equipment and materials limit its development in underdeveloped areas.

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