Fixed-point magnetorheological fluid delivery method and device
A magnetorheological fluid and fixed-point technology, which is applied in the direction of drug devices and other medical devices, can solve the problems of drug retention and accumulation in deep lesions in the body, and achieve the effect of time controllable and increased drug concentration
Active Publication Date: 2022-03-01
XI AN JIAOTONG UNIV
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Problems solved by technology
[0006] An object of the present invention is to provide a fixed-point magnetorheological fluid delivery method, which aims to solve the problem in the prior art that drugs cannot be retained and accumulated in deep lesions in the body under non-invasive conditions
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[0041] Further, see figure 1 , as a specific implementation of the magnetorheological fluid fixed-point delivery method provided by the present invention, step S4 is specifically:
[0042] Magneto-rheological fluid is applied to the body, and the magnetorheological fluid at the lesion position exhibits solid-like characteristics under the action of a magnetic field, stays at the lesion position and accumulates, realizing the "magnetic field deposition" of the magnetorheological fluid.
[0043] Specifically, magnetorheological fluid can be injected into the body through blood vessels, and the magnetorheological fluid in the area covered by the delivery area will converge to the magnetic field targeted delivery stagnation point 2 under the action of a magnetic field, changing the rheology of the magnetorheological fluid at the lesion The performance makes it present a solid-like characteristic, so that it can locally stay and gather at the lesion. Magnetorheological fluids may ...
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The invention discloses a fixed-point magnetorheological fluid delivery method and device. The method comprises the following steps that the focus position of an organism is determined; designing and manufacturing a targeted deposition magnetic field device to form a magnetic field targeted delivery retention point; overlapping the focus with a targeted delivery retention point; the magnetic field effect generated by the targeted deposition magnetic field device is used for achieving magnetic field deposition on the magnetorheological fluid in blood flow at the focus, so that the magnetorheological fluid is locally detained and gathered at a fixed point at the focus. The magnetorheological fluid can carry drugs or does not carry drugs, and the retention time of the magnetorheological fluid at the focus position is controllable. The targeted deposition magnetic field device arranged outside the body can generate a delivery retention point located inside the body, so that when a focus is located inside the body, the magnetorheological fluid can still be delivered to the position of the focus at a fixed point in a mode that the focus coincides with the delivery retention point and is retained in a limited time; the magnetorheological fluid can be retained in a deeper part in a machine body in a limited time manner, and the magnetorheological fluid can be recycled in a later period according to needs.
Description
technical field [0001] The invention relates to the field of magnetic drug delivery, in particular to a magnetorheological fluid fixed-point delivery method and device. Background technique [0002] For the drug targeting of diseases, especially tumors, the current main technical means include active targeting, passive targeting, physical targeting and other approaches. Among them, both active and passive targeting achieve drug aggregation in vivo to achieve targeting through certain rules (such as specific recognition of molecules, deposition in menstrual blood circulation, etc.). These technologies can achieve a certain degree of drug aggregation, but they all have problems such as targeting accuracy, low drug concentration levels, and large hitting areas. Physical targeting technology uses external physical environment such as temperature or magnetic field to transport and gather drugs to the lesion site. This type of technology can achieve better drug concentration at ...
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IPC IPC(8): A61M31/00
CPCA61M31/00
Inventor 刘志远王枫刘进军刘昊天冷婧贾子杰
Owner XI AN JIAOTONG UNIV