Rapid detection device for pharmaceutical raw materials

Abstract

The invention discloses a rapid detection device for pharmaceutical raw materials, which comprises an infrared spectrum detection mechanism. The infrared spectrum detection mechanism includes an infrared light emitting component, a first clamping component, a second clamping component and an infrared light receiving component arranged in sequence along the same line. Assemblies, the sheet pressing assembly includes a first window, a second window and a drive unit, the first window is arranged on the first clamping assembly, the second window is arranged on the second clamping assembly, the first window and the A sample gap for paraffin oil paste testing samples is formed between the second windows, and at least one of the first window and the second window can be driven by the driving unit to adjust the sample gap to a standard thickness. The rapid detection device provided by the present invention facilitates the adjustment and control of the thickness of the detection sample, and in the detection process, it is not necessary to move the paraffin oil paste detection sample, which effectively avoids the change in the thickness of the paraffin oil paste detection sample caused by the moving operation process, thereby Ensure the accuracy of detection.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a rapid detection device for drug raw materials. Background technique [0002] The molecules of pharmaceutical raw materials usually have different solid forms, including salts, polymorphs, co-crystals, amorphous, hydrates and solvates; There may be significant differences in properties such as bioavailability, which directly affects the efficacy and developability of the drug. If there is no good evaluation and selection of the best drug raw materials for research and development, the crystal form may change in the late clinical stage. , resulting in the delayed listing of the drug and huge economic losses. If the drug is forced to be withdrawn from the market due to changes in the crystal form after the listing, the loss will be even more severe. Therefore, drug crystal form research and drug solid state research and development are of great significance in the pharmace...

AI Technical Summary

Problems solved by technology

[0004] Paraffin oil is a kind of special long-chain alkanes with high viscosity and high refractive index. Its infrared spectrum is simple, and there are only 4 absorption bands in the mid-infrared region. The powder sample can be measured by the paraffin paste method, which is more effective for the sample without a suitable solvent by the solution method. The paraffin paste method generally takes 5-10 mg of the whole sample, grinds it finely in an agate mortar, and adds 1 to a few drops of liquid paraffin to grind it. Form a uniform paste (the particle size of the sample is controlled below 5 μm), and sandwich the paste between two detachable windows or two blank potassium bromide sheets for measurement. The thickness of the sample can be determined by using spacers and The degree of fastening is adjusted, and a clamping mechanism is provided on the infrared spectrum detection mechanism. Through the clamping mechanism, the paraffin oil paste test sample can be clamped and fixed to realize detection and analysis. The thickness of the paraffin oil paste test sample has an influence on the test result It is very large. The existing technology is to make paraffin oil paste test samples manually, and then fix the prepared paraffin oil paste test samples on the clamping mechanism. During the movement and operation, paraffin oil paste may be caused The thickness of the test sample changes, which affects the accuracy of the test

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