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Metal organic framework composite nanomaterial as well as preparation method and application thereof

A technology of composite nanomaterials and metal organic frameworks, applied in the field of biomedicine, can solve problems such as damage to tissues and organs, increase toxicity, etc., and achieve the effects of enhancing uptake, reducing leakage, and efficient chemokinetic diagnosis and treatment.

Pending Publication Date: 2022-03-25
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the non-specificity of drugs, while killing cancer cells, normal cells are also killed, damaging normal tissues and organs, and the sudden release of chemotherapy drugs will also increase their toxicity

Method used

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  • Metal organic framework composite nanomaterial as well as preparation method and application thereof
  • Metal organic framework composite nanomaterial as well as preparation method and application thereof
  • Metal organic framework composite nanomaterial as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] The synthesis of embodiment 1 copper metal organic framework material Cu-MOF

[0094] (1) Measure a mixture of oleic acid, ethanol and n-hexane with a volume ratio of 2:1:3 and stir at 50°C for 10 minutes to obtain a solution A for use;

[0095] (2) Weigh 40 mg of NaOH, dissolve it in 4 mL of water, add it to 10 mL of A solution, stir at 50°C for 10 minutes, and obtain B solution for use;

[0096] (3) Weigh 50mg Cu(NO 3 ) 2 ·3H 2 O, dissolve it in 1 mL of water, add it to solution B, stir at 50°C for 15 minutes, and obtain solution C for use;

[0097] (4) Weigh 50 mg of mellitic acid, dissolve it in 1.5 mL of ethanol / water (V / V=1.5:1), add it to solution C to obtain solution I, and stir solution I at 70°C for 2 hours , to obtain copper metal organic framework Cu-MOF;

[0098] (5) Centrifuge cyclohexane / ethanol (V / V=1:1) for 5 minutes at a rotational speed of 11000 rpm, centrifuge 3 times, and finally dissolve in N,N-dimethylformamide solution for use.

Embodiment 2

[0099] Example 2 Synthesis of copper metal organic framework material Cu-MOF

[0100] (1) Measure a mixture of oleic acid, ethanol and n-hexane with a volume ratio of 1:1:3 and stir at 50°C for 10 minutes to obtain a solution A for use;

[0101] (2) Weigh 40 mg of NaOH, dissolve it in 4 mL of water, add it to 10 mL of A solution, stir at 50°C for 10 minutes, and obtain B solution for use;

[0102] (3) Weigh 50mg Cu(NO 3 ) 2 ·3H 2O, dissolve it in 1 mL of water, add it to solution B, stir at 50°C for 15 minutes, and obtain solution C for use;

[0103] (4) Weigh 50 mg of mellitic acid, dissolve it in 1.5 mL of ethanol / water (V / V=1.5:1), add it to solution C to obtain solution I, and stir solution I at 70°C for 2 hours , to obtain copper metal organic framework Cu-MOF;

[0104] (5) Centrifuge cyclohexane / ethanol (V / V=1:1) for 5 minutes at a rotational speed of 11000 rpm, centrifuge 3 times, and finally dissolve in N,N-dimethylformamide solution for use.

Embodiment 3

[0105] Example 3 Synthesis of copper metal organic framework material Cu-MOF

[0106] (1) Measure a mixture of ethanol and n-hexane with a volume ratio of 1:3 and stir at 50°C for 10 minutes to obtain A solution for use;

[0107] (2) Weigh 40 mg of NaOH, dissolve it in 4 mL of water, add it to 10 mL of A solution, stir at 50°C for 10 minutes, and obtain B solution for use;

[0108] (3) Weigh 50mg Cu(NO 3 ) 2 ·3H 2 O, dissolve it in 1 mL of water, add it to solution B, stir at 50°C for 15 minutes, and obtain solution C for use;

[0109] (4) Weigh 50 mg of mellitic acid, dissolve it in 1.5 mL of ethanol / water (V / V=1.5:1), add it to solution C to obtain solution I, and stir solution I at 70°C for 6 hours , to obtain metal organic framework Cu-MOF;

[0110] (5) Centrifuge cyclohexane / ethanol (V / V=1:1) for 5 minutes at a rotational speed of 11000 rpm, centrifuge 3 times, and finally dissolve in N,N-dimethylformamide solution for use.

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Abstract

The invention discloses a metal organic framework composite nanomaterial as well as a preparation method and application thereof. The metal organic framework composite nano material comprises a functional material and a copper metal organic framework carrying the functional material, wherein the functional material comprises small organic molecules. The metal organic framework composite nanomaterial is good in chemical stability, has tumor microenvironment responsiveness, and can realize non-invasive, in-situ and efficient treatment and real-time monitoring of tumor parts.

Description

technical field [0001] The application relates to a metal-organic framework composite nanomaterial and its preparation method and application, belonging to the field of biomedicine. Background technique [0002] It is well known that highly toxic chemotherapeutic drugs need to be used in cancer chemotherapy. However, due to the non-specificity of drugs, while killing cancer cells, normal cells are also killed, damaging normal tissues and organs, and the sudden release of chemotherapy drugs will also increase their toxicity. In recent years, nanomaterials are not only used as drug carriers, but the diagnostic and therapeutic properties of nanomaterials themselves as nanomedicines have attracted widespread attention. Based on non-toxic / low-toxic nanomaterials, selectively catalyzing / triggering specific chemical reactions inside tumor tissues, and locally producing a considerable amount of specific reaction products, it is possible to achieve tumor specificity without causing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C09K11/06A61K41/00A61K33/34A61K49/00A61P35/00B82Y5/00
CPCC08G83/008C09K11/06A61K41/0076A61K33/34A61K49/0036A61K49/0054A61P35/00B82Y5/00C09K2211/188A61K2300/00
Inventor 马雪华陈天翔林杰吴爱国刘闯
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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