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Application of chalcone compounds in treatment of coronavirus infection

A technology of chalcones and coronaviruses, which is applied in the direction of antiviral agents, ketone active ingredients, drug combinations, etc., and can solve the problems of complex ingredients and toxic and harmful substances in traditional Chinese medicine

Pending Publication Date: 2022-03-29
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ingredients of traditional Chinese medicine are complex and diverse, and some Chinese medicines may contain toxic and harmful substances. Therefore, the identification of active ingredients that can exert antiviral effects is of great significance for the prevention and treatment of new coronary pneumonia

Method used

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  • Application of chalcone compounds in treatment of coronavirus infection
  • Application of chalcone compounds in treatment of coronavirus infection
  • Application of chalcone compounds in treatment of coronavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1. Screening of drug monomers with anti-SARS-CoV-2 activity from "three medicines and three prescriptions"

[0043] 1. Experimental method

[0044] 1. Cell culture and virus culture

[0045] The African green monkey kidney cell line Vero E6 was obtained from the American Type Culture Collection (ATCC, No. 1586) at 37°C, 5% CO 2 Under the condition of , cultured in DMEM medium (Gibco) containing 10% fetal bovine serum (FBS; Gibco Invitrogen).

[0046] The pangolin isolate xCoV (ie, GX_P2V / pangolin / 2017 / Guangxi) was propagated in Vero E6 cells, and the virus titer was determined by plaque assay. All infection experiments were performed in a biosafety level 2 (BLS2) laboratory.

[0047] Anti-COVID-19 Chinese medicine compound library (product number L6720, containing 389 kinds of Chinese medicine monomers separated and purified from "three medicines and three prescriptions") is a product of Shanghai Taosu Biochemical Technology Co., Ltd. The initial concentrati...

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Abstract

The invention discloses an application of chalcone compounds in treatment of coronavirus infection. The invention provides an application of a chalcone compound or a pharmaceutically acceptable salt thereof or a substance taking the chalcone compound or the pharmaceutically acceptable salt thereof as an active component in any one of the following steps: preparing a product for inhibiting coronavirus; products capable of treating diseases caused by coronavirus infection are prepared; products capable of improving symptoms caused by coronavirus infection can be prepared. According to the application disclosed by the invention, the active medicines, namely the acanthochalcone and the licochalcone B, which have the resistance to SARS-CoV-2 are screened from'three medicines and three prescriptions'. The invention has important clinical application value in treatment of COVID-19.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to the application of chalcone compounds in the treatment of coronavirus infection. Background technique [0002] The new coronavirus SARS-CoV-2 belongs to the Sarbecovirus subtype of Nidovirales, Coronaviridae, and Betacoronavirus. The diameter is 60~140nm. The SARS-CoV-2 virus is a single positive-strand RNA virus with a full-length genome of 29,903bp, and its sequence similarity with SARS-CoV and MERS-CoV is 78.7% and 48.7%, respectively, and it is derived from bat coronavirus strain Bat- SL-CoVZC45 is relatively close to Bat-SL-CoVZXC21, with a similarity of 87.5% and 87.3%, and is the closest to BetaCoV / bat / Yunnan / RaTG13 / 2013, with a similarity of 95.9%. At present, there is no specific drug for the novel coronavirus pneumonia (COVID-19) caused by SARS-CoV-2 virus infection, and the development of effective vaccines and specific drugs is crucial to suppress the spread and tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P11/00A61P31/14
CPCA61K31/12A61P11/00A61P31/14
Inventor 童贻刚范华昊胡运甲宋立华安小平王立钦秦宏博洪碧霞刘文丽陈杨桢
Owner BEIJING UNIV OF CHEM TECH