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Preparation method of hexagonal macroporous hydroxyapatite as well as product and application of hexagonal macroporous hydroxyapatite

A technology of macroporous hydroxyapatite and porous hydroxyapatite, which is applied in the field of biomedical materials and can solve the problems of restricting the delivery of macromolecular protein drugs and restricting the development and application of drugs

Active Publication Date: 2022-04-05
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, the pore size of nanometer-level mHAP is mostly below 5 nanometers, which limits their delivery of macromolecular protein drugs. Relevant research reports have found that once the macroporous structure is formed, hydroxyapatite will transform into Micron-scale materials, the large size of the micron-scale limits its further development and application on drug carriers

Method used

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  • Preparation method of hexagonal macroporous hydroxyapatite as well as product and application of hexagonal macroporous hydroxyapatite
  • Preparation method of hexagonal macroporous hydroxyapatite as well as product and application of hexagonal macroporous hydroxyapatite
  • Preparation method of hexagonal macroporous hydroxyapatite as well as product and application of hexagonal macroporous hydroxyapatite

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Embodiment 1

[0025] 1) Synthesis of carbon dots: 4-aminobenzoic acid (0.05g) and 0.05g of 1,4-diaminobenzene were dissolved in 10ml of absolute ethanol, and then these solutions were transferred to a polytetrafluoroethylene reactor and reacted at 180°C for 12h. After the reaction was completed, the reaction product was naturally cooled to room temperature. The obtained dark brown suspension was successively filtered, rotary evaporated, redissolved in deionized water, and centrifuged again. Then, the obtained black-brown carbon dot aqueous solution was dialyzed, and the molecular weight of the dialysis membrane was 500-1000 Da. Dialysis was performed with deionized water for 72 hours, and the water was changed every 6 hours. After removing small molecules, it was filtered. Finally, the collected black-brown solution was freeze-dried to obtain black powder, which was carbon dots.

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Abstract

The invention discloses a preparation method of hexagonal macroporous hydroxyapatite as well as a product and application thereof. The preparation method comprises the following steps: (1) preparing carbon dots; (2) compounding the carbon dots and hydroxyapatite; according to the invention, the carbon dots are used for replacing the traditional pore-foaming agent CTAB to synthesize the non-rod-shaped hexagonal mesoporous hydroxyapatite, and the size of the non-rod-shaped hexagonal mesoporous hydroxyapatite is controlled to be less than 200 nanometers and the pore diameter of the non-rod-shaped hexagonal mesoporous hydroxyapatite is about 10 nanometers, so that the non-rod-shaped hexagonal mesoporous hydroxyapatite can be better applied to delivery of macromolecular protein drugs. According to the carbon dots, benzoic acid containing amino and aminobenzene are adopted as raw materials, the morphology of the carbon dots is controlled, meanwhile, the carbon dots contain amino, the morphology of hydroxyapatite can be regulated and controlled, and compounding with hydroxyapatite can be better achieved. The experiment provides a method platform for synthesizing hydroxyapatite with fixed morphology and different mesoporous sizes. The mesoporous size of hydroxyapatite can be flexibly adjusted by utilizing different sizes of the synthesized carbon dots.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of hexagonal macroporous hydroxyapatite and its product and application. Background technique [0002] In recent years, people have paid more and more attention to the development of more effective new drug delivery systems. Compared with traditional drug delivery systems, new systems must have better bioavailability, high efficiency, low toxicity, and controlled release. So far, many materials including polymeric micelles, dendrimers, liposomes and various inorganic nanoparticles have been applied to drug delivery systems. Among them, mesoporous hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , referred to as mHAP) is favored by many scholars. Mesoporous hydroxyapatite has a macroporous structure and a large specific surface area, as well as the characteristics of easy surface modification, so that it can realize the targeted delivery of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K47/69A61K38/44B82Y5/00
Inventor 申婷婷弓小娟张晓兵
Owner HUNAN UNIV
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