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Particulate and/or nanoparticle separation, filtration and/or enrichment device and method

A nanoparticle, microparticle technology that can be used in filtration and/or enrichment systems, separation fields, and can solve problems that limit commercial applications.

Pending Publication Date: 2022-04-05
MONASH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While the system works extremely well for small, diagnostically relevant sample sizes, scaling the method beyond that scale would be challenging due to the required channel resonances
This limits the commercial application of the method

Method used

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  • Particulate and/or nanoparticle separation, filtration and/or enrichment device and method
  • Particulate and/or nanoparticle separation, filtration and/or enrichment device and method
  • Particulate and/or nanoparticle separation, filtration and/or enrichment device and method

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Embodiment Construction

[0067] As used herein, the term "nanoparticle" (NP) refers to a particle having a size measured in nanometers, and in some embodiments, the particle has a diameter between about 1 nm and 500 nm, such as greater than about 1 nm ; when used herein, the term "microparticle" (MP) refers to a particle having a size measured in micrometers or millimeters, and in some embodiments, a particle has a particle size between about 0.1 μm and 100 μm, such as greater than about 100 nm. diameter of.

[0068] Proof of concept for the described embodiments was demonstrated in a microfluidic system using microfluidic channels and microparticles, as described subsequently. However, it is contemplated that the described embodiments are used with more conventionally sized packed bed systems, as discussed below with reference to Figures 13-15, and thus, the described embodiments are not limited to use with microfluidic systems.

[0069] first reference figure 1 , shows a schematic diagram of a mic...

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Abstract

The invention discloses a particle and / or nanoparticle separation, filtration and / or enrichment device. The device comprises a flow channel through which a liquid suspension loaded with particles and / or nanoparticles can be guided; and at least one packed bed of particles physically retained within the flow channel through which the liquid suspension can pass. The apparatus also includes an ultrasonic actuation system for mechanically activating the or each packed bed during passage of the liquid suspension through the or each packed bed.

Description

technical field [0001] The present invention relates generally to separation, filtration and / or enrichment systems, and in particular to a separation, filtration and / or enrichment device and method for microparticles and nanoparticles. Background technique [0002] Isolation, enrichment and delivery of microparticles and nanoparticles form a critical part of the processing and research of submicron chemical, biological and biomedical substances. They have been used for virus or nanoparticle fusion of cells, detection and diagnosis, synthesis of nanoparticles, nanomedicine, nanoscale drug delivery, and nanowires. Furthermore, in the biological analysis of lysed cell fractions, DNA, viruses, and bacteria collect rare nanoparticles through different processes of enrichment by concentration, separation or isolation, filtration, and purification. In the field of biological and biomedical research, there has been a recent surge of interest in capturing extracellular vesicles (EVs...

Claims

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Application Information

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IPC IPC(8): G01N15/10G01N1/40G01N29/02
CPCB01L3/5027B01D24/305B01L2200/0652B01D61/147B01D61/145B01D61/18B01L3/502761B01L3/502715B01L3/50273B01L2400/0436B01L2300/0645B01L2300/0681B01L2300/0816B01L2400/0487B01D24/48B01D2101/00B01L2400/0439
Inventor R·哈比比A·尼尔
Owner MONASH UNIV