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A method for constructing metal-organic molecular complexes and inorganic phase hybrid functional coatings on degradable metal surfaces

A technology of organic molecules and construction methods, applied in coatings, medical science, prostheses, etc., can solve the problems of inability to take into account the regulation of zinc-based degradable metal corrosion behavior, the improvement of biocompatibility, and the lack of biological functionality. Achieve the effect of ensuring biocompatibility, stable and firm properties, and uniform and dense structure

Active Publication Date: 2022-08-02
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] In view of the above problems, the present invention provides a method for constructing metal-organic molecular composites and inorganic phase hybrid functional coatings on the surface of degradable metals, so as to solve the problems of zinc-based degradable metals in the existing surface modification technology. Regulation of corrosion behavior and improvement of biocompatibility, as well as the problem of insufficient biological functionality

Method used

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  • A method for constructing metal-organic molecular complexes and inorganic phase hybrid functional coatings on degradable metal surfaces
  • A method for constructing metal-organic molecular complexes and inorganic phase hybrid functional coatings on degradable metal surfaces
  • A method for constructing metal-organic molecular complexes and inorganic phase hybrid functional coatings on degradable metal surfaces

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Embodiment 1

[0040] A method for constructing a metal-organic molecular complex and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0041](1) Pre-treatment: Polish the pure zinc disc with 600#, 1200#, 2000# sandpaper in turn, and clean it with anhydrous ethanol under ultrasonic for 3 times, 5 minutes each time, and dry it at room temperature to the surface liquid volatilization;

[0042] (2) Preparation of zinc phosphate primer layer: 7.5mg / ml NaH 2 PO 4 and 2mg / ml of Zn(NO 3 ) 2 ·6H 2 After the O solution was mixed at a volume ratio of 5:2, it was placed in a 50°C water bath for 2h reaction, and then the dried zinc flakes in step (1) were placed in it, heated and reacted at 50°C for 2h, taken out and rinsed with water. Then place it in a constant temperature drying oven at 37°C to dry until the surface liquid volatilizes;

[0043] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water with a material-to-liquid ratio...

Embodiment 2

[0048] A method for constructing a metal-organic molecular complex and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0049] (1) Pre-treatment: The pure magnesium sample is polished with 600#, 1200#, 2000# sandpaper in turn, and washed with absolute ethanol under ultrasonic for 3 times, 4 minutes each time, and dried at room temperature until the surface is liquid volatilize;

[0050] (2) Preparation of zinc phosphate primer layer: 6mg / ml Na 2 HPO 4 and 1mg / ml of Zn(NO 3 ) 6H 2 After the O solution was mixed at a volume ratio of 5:2, it was placed in a 50°C water bath for 2 hours of reaction, and then the dried sample in step (1) was placed in it, heated and reacted at 60°C for 1.5 hours, then taken out and rinsed with water. Then dry at room temperature until the surface liquid volatilizes;

[0051] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water at a material-to-liquid ratio of 1.5mg:1mg:1ml, st...

Embodiment 3

[0056] A method for constructing a metal-organic molecular complex and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0057] (1) Pre-treatment: The pure iron sample is polished to remove the surface oxide layer to expose the pure iron, and washed with absolute ethanol for 3 times under ultrasonic for 6 minutes each time, and dried at room temperature until the surface liquid volatilizes;

[0058] (2) Preparation of zinc phosphate primer layer: 9mg / ml Na 2 HPO 4 and 3mg / ml of Zn(NO 3 ) 6H 2 After the O solution was mixed in a volume ratio of 5:2, it was placed in a water bath at 50 °C for 2 hours, and then the pure magnesium sample dried in step (1) was placed in it, heated at 40 °C for 2.5 hours, and washed with water. Clean, and then dry at room temperature until the surface liquid evaporates;

[0059] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water with a material-to-liquid ratio of 5mg:2mg:1ml, ...

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Abstract

The invention discloses a method for constructing a metal-organic molecular complex and an inorganic phase hybrid functional coating on a degradable metal surface. The method firstly uses a liquid phase chemical deposition method to form a layer on the untreated degradable metal surface Rough and stable inorganic zinc phosphate coating; then degradable metal with inorganic zinc phosphate coating on the surface is cyclically alternately evaporated and deposited in collagen / ferulic acid / hydroxyethylidene diphosphate mixed solution and metal ion solution to obtain metal ‑Organic molecular complex and inorganic phase hybrid functional coating. In the present invention, through the chemical coordination between organic functional molecules, metal ions and inorganic components, the composite hybrid forms a dense, uniform metal-organic molecule complex with high hydrophilicity and surface energy and an inorganic phase hybrid. The chemical functional coating has good osseointegration, bone regeneration, angiogenesis, antibacterial and anti-inflammatory biological functions while taking into account the corrosion degradation control and biocompatibility of degradable metals.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a method for constructing a metal-organic molecule complex and an inorganic phase hybrid functional coating on a degradable metal surface. Background technique [0002] Compared with traditional metal implant materials, degradable metal as a temporary implant has significant advantages such as avoiding secondary surgery and accelerating the healing process, thereby greatly reducing the risk. Based on the above advantages, degradable zinc materials have gradually entered people's field of vision and attracted widespread attention. So far, degradable metals are mainly divided into magnesium, iron and zinc. Compared with magnesium and iron, degradable metal zinc is expected to be used in the treatment of orthopedic and cardiovascular diseases due to its relatively moderate corrosion rate and potential biological functionality. However, the lack of good corrosion degradat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/28A61L27/30A61L27/04A61L27/50A61L27/54A61L27/58
Inventor 万国江王鹏钱军余张文泰王佳乐林雪毛金龙黄楠
Owner SOUTHWEST JIAOTONG UNIV
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