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Gene acting on hypertension blood stasis and detection primer thereof

A technology for detecting primers and high blood pressure, applied in genetic engineering, plant genetic improvement, microbial measurement/testing, etc., can solve problems such as diseases, achieve the effects of dilating blood vessels, improving hypertension and blood stasis, and improving vascular endothelial function

Pending Publication Date: 2022-04-12
陈利国
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moderate endoplasmic reticulum stress can maintain the homeostasis of the internal environment by rapidly regulating intracellular Ca2+ balance, protein folding modification, and cell apoptosis, so that cells can continuously adapt to changes in the environment and play a protective role. Plasma reticulum stress can cause disease

Method used

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  • Gene acting on hypertension blood stasis and detection primer thereof
  • Gene acting on hypertension blood stasis and detection primer thereof
  • Gene acting on hypertension blood stasis and detection primer thereof

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Experimental program
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Embodiment 1

[0026] 1. Experimental animals: ATF4 knockout C57BL / 6J mice were purchased from Nanjing Institute of Animal Modeling, wild-type C57BL / 6J mice were purchased from the Animal Center of Southern Medical University, and were raised in an SPF-level barrier environment in the Experimental Animal Management Center of Jinan University.

[0027] 2. Animal grouping: 18 ATF4 knockout C57BL / 6J strain mice, 18 wild-type mice. Divided into gene knockout + normal diet group (KO-NS: 6 rats), gene knockout + 8% high-salt diet group (KO-HS: 12 rats), wild type + normal diet group (WT-NS: 6 rats ), wild type+8% high-salt diet group (WT-HS: 12 rats).

[0028] 3. Modeling method: WT-NS group and KO-NS group were fed with normal mouse feed, and WT-HS group and KO-HS group were fed with 8% high-salt feed customized by Nantong Trophy Company. Drink water freely and feed for 28 days; on the 29th day, the mouse thoracic aorta and mouse serum were taken for Western blot and Elisa detection.

[0029] 4...

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Abstract

The invention discloses a gene acting on hypertension blood stasis and a detection primer thereof. The influence of an ATF4 gene on the contents of NO, ET-1, EPCR, TM, vWF, tPA and PAI in an animal body is researched. It is found that the ATF4 gene can influence expression of ET-1, EPCR, TM, vWF, PAI, NO and tPA, so that the blood pressure and blood stasis conditions of animals are correspondingly adjusted, and people can conveniently develop the medicine for adjusting the blood pressure and blood stasis conditions.

Description

technical field [0001] The invention belongs to the biological field, and in particular relates to a gene acting on hypertension and blood stasis and a detection primer thereof. Background technique [0002] Hypertension is a chronic disease with sustained high arterial blood pressure. It is also the most important risk-promoting factor for ischemic heart disease, cerebrovascular damage, and arteriosclerosis. It is currently the disease with the most serious cardiovascular and cerebrovascular complications in my country. Recent studies have shown that blood stasis plays an important role in the progression of the disease in hypertensive patients. Blood stasis accounts for 47% of hypertensive patients, and blood stasis symptoms can appear in different degrees in different periods of hypertension. [0003] Traditional Chinese medicine believes that any blood that leaves the menstrual flow and accumulates in the body or blood stagnates in the organs, viscera, and tissues, causi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C12N15/11C12Q1/6883A61K45/00A61K31/7088A61P9/12
Inventor 陈利国梁秋儿陈伟豪陈旭东谢鹏程谢婷涂宛晴林丽群肖雅刘天浩
Owner 陈利国
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